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Literature DB >> 23087779

Genetic Susceptibility to Fungal Infections in Humans.

Abstract

Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that typically involve mucocutaneous surfaces. Hence, when persistent or recurrent mucocutaneous infections (chronic mucocutaneous candidiasis [CMC]) or invasive fungal infections (IFIs) develop in a "normal" host, they are indicative of genetic defects causing innate or adaptive immune dysfunction. In this review, recent developments concerning genetic and immunologic factors that affect the risk for IFIs and CMC are critically discussed.

Entities: Chemical Disease Gene Mutation Species

Year: 2011 PMID： 23087779 PMCID： PMC3475324 DOI： 10.1007/s12281-011-0076-4

Source DB: PubMed Journal: Curr Fungal Infect Rep ISSN： 1936-3761

99 in total

1. Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis.

Authors: A Bozzi; P P N Pereira; B S Reis; M I Goulart; M C N Pereira; E P Pedroso; M F Leite; A M Goes
Journal: Hum Immunol Date: 2006-09-01 Impact factor: 2.850

Review 2. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature.

Authors: P E Tarr; M C Sneller; L J Mechanic; A Economides; C M Eger; W Strober; C Cunningham-Rundles; D R Lucey
Journal: Medicine (Baltimore) Date: 2001-03 Impact factor: 1.889

3. Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.

Authors: Brahm H Segal; Lisa A Barnhart; Victoria L Anderson; Thomas J Walsh; Harry L Malech; Steven M Holland
Journal: Clin Infect Dis Date: 2005-04-29 Impact factor: 9.079

4. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome with renal failure: impact of posttransplant immunosuppression on disease activity.

Authors: Tim Ulinski; Laurence Perrin; Michael Morris; Muriel Houang; Sylvie Cabrol; Christine Grapin; Nathalie Chabbert-Buffet; Albert Bensman; Georges Deschênes; Irina Giurgea
Journal: J Clin Endocrinol Metab Date: 2005-11-01 Impact factor: 5.958

5. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes.

Authors: W Marhoffer; M Stein; E Maeser; K Federlin
Journal: Diabetes Care Date: 1992-02 Impact factor: 19.112

6. Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000.

Authors: Theoklis E Zaoutis; Kateri Heydon; Jaclyn H Chu; Thomas J Walsh; William J Steinbach
Journal: Pediatrics Date: 2006-03-13 Impact factor: 7.124

7. Successful treatment of Fusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions.

Authors: Fethi Mellouli; Habib Ksouri; Ridha Barbouche; Mongi Maamer; Leila Ben Hamed; Slama Hmida; Assia Ben Hassen; Mohamed Béjaoui
Journal: BMC Dermatol Date: 2010-10-07

8. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation.

Authors: Pierre-Yves Bochud; Jason W Chien; Kieren A Marr; Wendy M Leisenring; Arlo Upton; Marta Janer; Stephanie D Rodrigues; Sarah Li; John A Hansen; Lue Ping Zhao; Alan Aderem; Michael Boeckh
Journal: N Engl J Med Date: 2008-10-23 Impact factor: 91.245

9. Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis.

Authors: A Bozzi; B S Reis; P P Pereira; E P Pedroso; A M Goes
Journal: Cytokine Date: 2009-08-13 Impact factor: 3.861

10. Restoration of NET formation by gene therapy in CGD controls aspergillosis.

Authors: Matteo Bianchi; Abdul Hakkim; Volker Brinkmann; Ulrich Siler; Reinhard A Seger; Arturo Zychlinsky; Janine Reichenbach
Journal: Blood Date: 2009-06-18 Impact factor: 22.113

20 in total

1. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

Authors: Michail S Lionakis; Muthulekha Swamydas; Brett G Fischer; Theo S Plantinga; Melissa D Johnson; Martin Jaeger; Nathaniel M Green; Andrius Masedunskas; Roberto Weigert; Constantinos Mikelis; Wuzhou Wan; Chyi-Chia Richard Lee; Jean K Lim; Aymeric Rivollier; John C Yang; Greg M Laird; Robert T Wheeler; Barbara D Alexander; John R Perfect; Ji-Liang Gao; Bart-Jan Kullberg; Mihai G Netea; Philip M Murphy
Journal: J Clin Invest Date: 2013-11-01 Impact factor: 14.808

Genetic Susceptibility to Fungal Infections in Humans.

1. Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis.

Review 2. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature.

3. Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.

4. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome with renal failure: impact of posttransplant immunosuppression on disease activity.

5. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes.

6. Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000.

7. Successful treatment of Fusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions.

8. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation.

9. Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis.

10. Restoration of NET formation by gene therapy in CGD controls aspergillosis.

1. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

2. CARD9: at the intersection of mucosal and systemic antifungal immunity.

Review 3. Antifungal drug development: challenges, unmet clinical needs, and new approaches.

Review 4. Host genetics of invasive Aspergillus and Candida infections.

Review 5. Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies.

Review 6. Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands.

Review 7. Learning from other diseases: protection and pathology in chronic fungal infections.

8. Genetic Susceptibility to Fungal Infections: What is in the Genes?

Review 9. Primary immunodeficiencies underlying fungal infections.

Review 10. Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street.