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Literature DB >> 27547700

Genetic Susceptibility to Fungal Infections: What is in the Genes?

Stacey A Maskarinec¹, Melissa D Johnson², John R Perfect¹.

Abstract

The development of severe fungal infections has long been associated with traditional risk factors such as profound immunosuppression, yet it remains challenging to understand why under similar conditions only some patients will develop these infections while others will not. Recent studies have demonstrated the importance of host genetic variation in influencing the severity and susceptibility to invasive fungal infections (IFIs). In this review, we examine selected primary immunodeficiencies characterized by their vulnerability to a narrow range of fungal pathogens, and then focus on recently identified genetic polymorphisms associated with an increased susceptibility to IFIs.

Entities: Chemical Disease Gene Mutation Species

Keywords: Cryptococcus; Genetic susceptibility; Invasive Candida infection; Invasive aspergillosis; Single-nucleotide polymorphism

Year: 2016 PMID： 27547700 PMCID： PMC4988683 DOI： 10.1007/s40588-016-0037-3

Source DB: PubMed Journal: Curr Clin Microbiol Rep ISSN： 2196-5471

99 in total

1. Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation.

Authors: Miquel Granell; Alvaro Urbano-Ispizua; Belén Suarez; Montserrat Rovira; Francesc Fernández-Avilés; Carmen Martínez; Mar Ortega; Carla Uriburu; Anna Gaya; Josep M A Roncero; Alfons Navarro; Enric Carreras; Josep Mensa; Jordi Vives; Ciril Rozman; Emili Montserrat; Francisco Lozano
Journal: Exp Hematol Date: 2006-10 Impact factor: 3.084

Review 2. Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis.

Authors: Taylor R T Dagenais; Nancy P Keller
Journal: Clin Microbiol Rev Date: 2009-07 Impact factor: 26.132

3. Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection.

Authors: Chantal A A Van der Graaf; Mihai G Netea; Servaas A Morré; Martin Den Heijer; Paul E Verweij; Jos W M Van der Meer; Bart Jan Kullberg
Journal: Eur Cytokine Netw Date: 2006-03 Impact factor: 2.737

4. Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis.

Authors: Paulo C Giraldo; Oksana Babula; Ana Katherine S Gonçalves; Iara M Linhares; Rose Luce Amaral; William J Ledger; Steven S Witkin
Journal: Obstet Gynecol Date: 2007-05 Impact factor: 7.661

5. Mannose-binding lectin deficiency facilitates abdominal Candida infections in patients with secondary peritonitis.

Authors: J W Olivier van Till; Piet W Modderman; Martin de Boer; Margreet H L Hart; Marcel G H M Beld; Marja A Boermeester
Journal: Clin Vaccine Immunol Date: 2007-10-31

6. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation.

Authors: Pierre-Yves Bochud; Jason W Chien; Kieren A Marr; Wendy M Leisenring; Arlo Upton; Marta Janer; Stephanie D Rodrigues; Sarah Li; John A Hansen; Lue Ping Zhao; Alan Aderem; Michael Boeckh
Journal: N Engl J Med Date: 2008-10-23 Impact factor: 91.245

7. Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome.

Authors: Ahinoam Lev-Sagie; Diana Prus; Iara M Linhares; Yuval Lavy; William J Ledger; Steven S Witkin
Journal: Am J Obstet Gynecol Date: 2009-03 Impact factor: 8.661

Review 8. Human genetic susceptibility to infectious disease.

Authors: Stephen J Chapman; Adrian V S Hill
Journal: Nat Rev Genet Date: 2012-02-07 Impact factor: 53.242

9. The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus.

Authors: Chad Steele; Rekha R Rapaka; Allison Metz; Shannon M Pop; David L Williams; Siamon Gordon; Jay K Kolls; Gordon D Brown
Journal: PLoS Pathog Date: 2005-12-09 Impact factor: 6.823

Review 10. New insights into innate immune control of systemic candidiasis.

Authors: Michail S Lionakis
Journal: Med Mycol Date: 2014-07-14 Impact factor: 4.076

13 in total

1. Invasive Fungal Infection.

Authors: Marie von Lilienfeld-Toal; Johannes Wagener; Hermann Einsele; Oliver A Cornely; Oliver Kurzai
Journal: Dtsch Arztebl Int Date: 2019-04-19 Impact factor: 5.594

2. Dectin-1 rs3901533 and rs7309123 Polymorphisms Increase Susceptibility to Pulmonary Invasive Fungal Disease in Patients with Acute Myeloid Leukemia from a Chinese Han Population.

Authors: Mei-Jing Chen; Rong Hu; Xiao-Ying Jiang; Yong Wu; Zhi-Peng He; Jing-Yi Chen; Li Zhan
Journal: Curr Med Sci Date: 2019-12-16

Review 3. How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts.

Authors: Steven T Denham; Morgan A Wambaugh; Jessica C S Brown
Journal: J Mol Biol Date: 2019-05-09 Impact factor: 5.469

4. Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis.

Authors: M Jurado; J Sainz; C B Lupiañez; M Martínez-Bueno; J M Sánchez-Maldonado; J Badiola; C Cunha; J Springer; M Lackner; J Segura-Catena; L M Canet; L Alcazar-Fuoli; M A López-Nevot; L Fianchi; J M Aguado; L Pagano; E López-Fernández; M Alarcón-Riquelme; L Potenza; S M Gonçalves; M Luppi; L Moratalla; C Solano; A Sampedro; P González-Sierra; M Cuenca-Estrella; K Lagrou; J A Maertens; C Lass-Flörl; H Einsele; L Vazquez; J Loeffler; R Ríos-Tamayo; A Carvalho
Journal: Infect Immun Date: 2020-03-23 Impact factor: 3.441

5. Acidic Mammalian Chitinase Negatively Affects Immune Responses during Acute and Chronic Aspergillus fumigatus Exposure.

Authors: Jaleesa M Garth; Joseph J Mackel; Kristen M Reeder; Jonathan P Blackburn; Chad W Dunaway; Zhihong Yu; Sadis Matalon; Lori Fitz; Chad Steele
Journal: Infect Immun Date: 2018-06-21 Impact factor: 3.441

Review 9. Challenges and Opportunities in Understanding Genetics of Fungal Diseases: Towards a Functional Genomics Approach.

Authors: Mariolina Bruno; Vasiliki Matzaraki; Frank L van de Veerdonk; Vinod Kumar; Mihai G Netea
Journal: Infect Immun Date: 2021-07-15 Impact factor: 3.441

Review 10. New Horizons in Antifungal Therapy.

Authors: Kaila M Pianalto; J Andrew Alspaugh
Journal: J Fungi (Basel) Date: 2016-10-02