OBJECTIVE: Many EEG studies have reported that ADHD is characterized by elevated Theta/Beta ratio (TBR). In this study we conducted a meta-analysis on the TBR in ADHD. METHOD: TBR data during Eyes Open from location Cz were analyzed from children/adolescents 6-18 years of age with and without ADHD. RESULTS: Nine studies were identified with a total of 1253 children/adolescents with and 517 without ADHD. The grand-mean effect size (ES) for the 6-13 year-olds was 0.75 and for the 6-18 year-olds was 0.62. However the test for heterogeneity remained significant; therefore these ESs are misleading and considered an overestimation. Post-hoc analysis found a decreasing difference in TBR across years, explained by an increasing TBR for the non-ADHD groups. CONCLUSION: Excessive TBR cannot be considered a reliable diagnostic measure of ADHD, however a substantial sub-group of ADHD patients do deviate on this measure and TBR has prognostic value in this sub-group, warranting its use as a prognostic measure rather than a diagnostic measure.
OBJECTIVE: Many EEG studies have reported that ADHD is characterized by elevated Theta/Beta ratio (TBR). In this study we conducted a meta-analysis on the TBR in ADHD. METHOD:TBR data during Eyes Open from location Cz were analyzed from children/adolescents 6-18 years of age with and without ADHD. RESULTS: Nine studies were identified with a total of 1253 children/adolescents with and 517 without ADHD. The grand-mean effect size (ES) for the 6-13 year-olds was 0.75 and for the 6-18 year-olds was 0.62. However the test for heterogeneity remained significant; therefore these ESs are misleading and considered an overestimation. Post-hoc analysis found a decreasing difference in TBR across years, explained by an increasing TBR for the non-ADHD groups. CONCLUSION: Excessive TBR cannot be considered a reliable diagnostic measure of ADHD, however a substantial sub-group of ADHDpatients do deviate on this measure and TBR has prognostic value in this sub-group, warranting its use as a prognostic measure rather than a diagnostic measure.
Authors: Madeline M Robertson; Sarah Furlong; Bradley Voytek; Thomas Donoghue; Charlotte A Boettiger; Margaret A Sheridan Journal: J Neurophysiol Date: 2019-10-16 Impact factor: 2.714
Authors: Sandra K Loo; Robert M Bilder; Alexander L Cho; Alexandra Sturm; Jennifer Cowen; Patricia Walshaw; Jennifer Levitt; Melissa Del'Homme; John Piacentini; James J McGough; James T McCracken Journal: J Am Acad Child Adolesc Psychiatry Date: 2016-05-21 Impact factor: 8.829