Literature DB >> 23085880

Highlights from the International Transporter Consortium second workshop.

M J Zamek-Gliszczynski1, K A Hoffmaster, D J Tweedie, K M Giacomini, K M Hillgren.   

Abstract

The Second International Transporter Consortium (ITC) Workshop was held with the purpose of expanding on previous white-paper recommendations, discussing recent regulatory draft guidance documents on transporter-drug interactions, and highlighting transporter-related challenges in drug development. Specific goals were to discuss additional clinically relevant transporters (MATEs, MRP2, BSEP) and best-practice methodologies and to re-evaluate ITC decision trees based on actual case studies. The outcome of the workshop will be a series of white papers targeted for publication in 2013.

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Year:  2012        PMID： 23085880     DOI： 10.1038/clpt.2012.126

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  21 in total

1.  The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.

Authors:  Joao N Dos Santos Pereira; Sina Tadjerpisheh; Manar Abu Abed; Ali R Saadatmand; Babette Weksler; Ignacio A Romero; Pierre-Olivier Couraud; Jürgen Brockmöller; Mladen V Tzvetkov
Journal:  AAPS J       Date:  2014-08-26       Impact factor: 4.009

Review 2.  Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 Proteins.

Authors:  Dustin R Walsh; Thomas D Nolin; Peter A Friedman
Journal:  Pharmacol Rev       Date:  2015-07       Impact factor: 25.468

Review 3.  Drug-drug interaction studies: regulatory guidance and an industry perspective.

Authors:  Thomayant Prueksaritanont; Xiaoyan Chu; Christopher Gibson; Donghui Cui; Ka Lai Yee; Jeanine Ballard; Tamara Cabalu; Jerome Hochman
Journal:  AAPS J       Date:  2013-03-30       Impact factor: 4.009

4.  MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption.

Authors:  Josef Reznicek; Martina Ceckova; Zuzana Ptackova; Ondrej Martinec; Lenka Tupova; Lukas Cerveny; Frantisek Staud
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

5.  Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse.

Authors:  Tomotaka Shingaki; W Ewan Hume; Tadayuki Takashima; Yumiko Katayama; Takashi Okauchi; Emi Hayashinaka; Yasuhiro Wada; Yilong Cui; Hiroyuki Kusuhara; Yuichi Sugiyama; Yasuyoshi Watanabe
Journal:  Pharm Res       Date:  2015-02-27       Impact factor: 4.200

Review 6.  Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

Authors:  K L R Brouwer; L M Aleksunes; B Brandys; G P Giacoia; G Knipp; V Lukacova; B Meibohm; S K Nigam; M Rieder; S N de Wildt
Journal:  Clin Pharmacol Ther       Date:  2015-09       Impact factor: 6.875

7.  Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach.

Authors:  Gurpreet K Grewal; Khuraijam D Singh; Neha Kanojia; Chitra Rawat; Samiksha Kukal; Ajay Jajodia; Anshika Singhal; Richa Misra; Selvaraman Nagamani; Karthikeyan Muthusamy; Ritushree Kukreti
Journal:  Pharm Res       Date:  2017-04-21       Impact factor: 4.200

8.  Cadmium exposure enhances organic cation transporter 2 trafficking to the kidney membrane and exacerbates cisplatin nephrotoxicity.

Authors:  Hong Yang; Jie Tang; Dong Guo; Qingqing Zhao; Jiagen Wen; Yanjuan Zhang; Obinna N Obianom; Shiwei Zhou; Wei Zhang; Yan Shu
Journal:  Kidney Int       Date:  2019-11-26       Impact factor: 10.612

Review 9.  ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.

Authors:  M J Zamek-Gliszczynski; C A Lee; A Poirier; J Bentz; X Chu; H Ellens; T Ishikawa; M Jamei; J C Kalvass; S Nagar; K S Pang; K Korzekwa; P W Swaan; M E Taub; P Zhao; A Galetin
Journal:  Clin Pharmacol Ther       Date:  2013-02-25       Impact factor: 6.875

Review 10.  Molecular modeling and ligand docking for solute carrier (SLC) transporters.

Authors:  Avner Schlessinger; Natalia Khuri; Kathleen M Giacomini; Andrej Sali
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295
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