Literature DB >> 26088472

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

K L R Brouwer1, L M Aleksunes2, B Brandys3, G P Giacoia4, G Knipp5, V Lukacova6, B Meibohm7, S K Nigam8, M Rieder9, S N de Wildt10.   

Abstract

The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
© 2015 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2015        PMID： 26088472      PMCID： PMC4731327          DOI： 10.1002/cpt.176

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  80 in total

1.  Expression and cellular distribution during development of the peptide transporter (PepT1) in the small intestinal epithelium of the rat.

Authors:  I Hussain; L Kellett; J Affleck; J Shepherd; R Boyd
Journal:  Cell Tissue Res       Date:  2001-11-08       Impact factor: 5.249

2.  Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos.

Authors:  A Konieczna; B Erdösová; R Lichnovská; M Jandl; K Cížková; J Ehrmann
Journal:  J Mol Histol       Date:  2011-10-20       Impact factor: 2.611

Review 3.  Membrane transporters in drug development.

Authors:  Kathleen M Giacomini; Shiew-Mei Huang; Donald J Tweedie; Leslie Z Benet; Kim L R Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M Hillgren; Keith A Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B Kim; Caroline A Lee; Mikko Niemi; Joseph W Polli; Yuichi Sugiyama; Peter W Swaan; Joseph A Ware; Stephen H Wright; Sook Wah Yee; Maciej J Zamek-Gliszczynski; Lei Zhang
Journal:  Nat Rev Drug Discov       Date:  2010-03       Impact factor: 84.694

4.  Regulatory experience with physiologically based pharmacokinetic modeling for pediatric drug trials.

Authors:  R Leong; M L T Vieira; P Zhao; Y Mulugeta; C S Lee; S-M Huang; G J Burckart
Journal:  Clin Pharmacol Ther       Date:  2012-05       Impact factor: 6.875

5.  Developmental expression of canalicular transporter genes in human liver.

Authors:  Huey-Ling Chen; Hui-Ling Chen; Yu-Jung Liu; Chun-Hsiang Feng; Chao-Yi Wu; Ming-Kwang Shyu; Ray-Hwang Yuan; Mei-Hwei Chang
Journal:  J Hepatol       Date:  2005-09       Impact factor: 25.083

Review 6.  An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research.

Authors:  Rena Li; Yong Shen
Journal:  Life Sci       Date:  2013-02-27       Impact factor: 5.037

7.  Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat.

Authors:  M V St-Pierre; T Stallmach; A Freimoser Grundschober; J-F Dufour; M A Serrano; J J G Marin; Y Sugiyama; P J Meier
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2004-09-02       Impact factor: 3.619

8.  Differential expression of bile salt and organic anion transporters in developing rat liver.

Authors:  Bo Gao; Marie V St Pierre; Bruno Stieger; Peter J Meier
Journal:  J Hepatol       Date:  2004-08       Impact factor: 25.083

9.  UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.

Authors:  Tsuyoshi Fukuda; Jens Goebel; Shareen Cox; Denise Maseck; Kejian Zhang; Joseph R Sherbotie; Eileen N Ellis; Laura P James; Robert M Ward; Alexander A Vinks
Journal:  Ther Drug Monit       Date:  2012-12       Impact factor: 3.681

10.  Genetic and epigenetic regulation of gene expression in fetal and adult human livers.

Authors:  Marc Jan Bonder; Silva Kasela; Mart Kals; Riin Tamm; Kaie Lokk; Isabel Barragan; Wim A Buurman; Patrick Deelen; Jan-Willem Greve; Maxim Ivanov; Sander S Rensen; Jana V van Vliet-Ostaptchouk; Marcel G Wolfs; Jingyuan Fu; Marten H Hofker; Cisca Wijmenga; Alexandra Zhernakova; Magnus Ingelman-Sundberg; Lude Franke; Lili Milani
Journal:  BMC Genomics       Date:  2014-10-04       Impact factor: 3.969
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  53 in total

1.  The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions.

Authors:  C Rafaniello; M Sessa; F F Bernardi; M Pozzi; S Cheli; D Cattaneo; S Baldelli; M Molteni; R Bernardini; F Rossi; E Clementi; C Bravaccio; S Radice; A Capuano
Journal:  Pharmacogenomics J       Date:  2017-07-18       Impact factor: 3.550

Review 2.  The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.

Authors:  Sanjay K Nigam
Journal:  Annu Rev Pharmacol Toxicol       Date:  2018-01-06       Impact factor: 13.820

3.  Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation.

Authors:  Jeremiah D Momper; Jin Yang; Mary Gockenbach; Florin Vaida; Sanjay K Nigam
Journal:  Clin J Am Soc Nephrol       Date:  2019-03-18       Impact factor: 8.237

4.  Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.

Authors:  Cindy Yanfei Li; Chelsea Hosey-Cojocari; Abdul Basit; Jashvant D Unadkat; J Steven Leeder; Bhagwat Prasad
Journal:  AAPS J       Date:  2019-07-11       Impact factor: 4.009

Review 5.  Design and conduct of early phase drug studies in children: challenges and opportunities.

Authors:  Michael Rieder; Daniel Hawcutt
Journal:  Br J Clin Pharmacol       Date:  2016-08-08       Impact factor: 4.335

Review 6.  Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.

Authors:  Daniel Scotcher; Christopher Jones; Maria Posada; Amin Rostami-Hodjegan; Aleksandra Galetin
Journal:  AAPS J       Date:  2016-06-30       Impact factor: 4.009

7.  Prediction of Drug Clearance from Enzyme and Transporter Kinetics.

Authors:  Priyanka R Kulkarni; Amir S Youssef; Aneesh A Argikar
Journal:  Methods Mol Biol       Date:  2021

Review 8.  Disruption of small molecule transporter systems by Transporter-Interfering Chemicals (TICs).

Authors:  Sascha C T Nicklisch; Amro Hamdoun
Journal:  FEBS Lett       Date:  2020-12-09       Impact factor: 4.124

9.  Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients.

Authors:  Hanna Kim; Kristina M Brooks; Cheng Cai Tang; Paul Wakim; Mary Blake; Stephen R Brooks; Gina A Montealegre Sanchez; Adriana A de Jesus; Yan Huang; Wanxia Li Tsai; Massimo Gadina; Apurva Prakash; Jonathan Marcus Janes; Xin Zhang; William L Macias; Parag Kumar; Raphaela Goldbach-Mansky
Journal:  Clin Pharmacol Ther       Date:  2017-12-08       Impact factor: 6.875

10.  Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.

Authors:  Margaret M S Thomson; Ronald N Hines; Erin G Schuetz; Bernd Meibohm
Journal:  Drug Metab Dispos       Date:  2016-04-20       Impact factor: 3.922
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