Literature DB >> 23588311

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.

M J Zamek-Gliszczynski1, C A Lee, A Poirier, J Bentz, X Chu, H Ellens, T Ishikawa, M Jamei, J C Kalvass, S Nagar, K S Pang, K Korzekwa, P W Swaan, M E Taub, P Zhao, A Galetin.   

Abstract

This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter-knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter-mediated pharmacokinetics and drug-drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in vitro, in vivo, and modeling tools in translational transporter science.

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Year:  2013        PMID： 23588311      PMCID： PMC3898877          DOI： 10.1038/clpt.2013.45

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  73 in total

1.  Models to predict unbound intracellular drug concentrations in the presence of transporters.

Authors:  Ken R Korzekwa; Swati Nagar; Jalia Tucker; Erica A Weiskircher; Siddhartha Bhoopathy; Ismael J Hidalgo
Journal:  Drug Metab Dispos       Date:  2012-01-25       Impact factor: 3.922

2.  Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein.

Authors:  T Tachibana; M Kato; T Watanabe; T Mitsui; Y Sugiyama
Journal:  Xenobiotica       Date:  2009-06       Impact factor: 1.908

3.  If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

Authors:  Annie Albin Lumen; Poulomi Acharya; Joseph W Polli; Andrew Ayrton; Harma Ellens; Joe Bentz
Journal:  Drug Metab Dispos       Date:  2009-11-04       Impact factor: 3.922

4.  Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

Authors:  Hannah M Jones; Hugh A Barton; Yurong Lai; Yi-An Bi; Emi Kimoto; Sarah Kempshall; Sonya C Tate; Ayman El-Kattan; J Brian Houston; Aleksandra Galetin; Katherine S Fenner
Journal:  Drug Metab Dispos       Date:  2012-02-16       Impact factor: 3.922

5.  Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier.

Authors:  Rong Zhao; Thomas J Raub; Geri A Sawada; Steven C Kasper; James A Bacon; Arlene S Bridges; Gary M Pollack
Journal:  Drug Metab Dispos       Date:  2009-03-09       Impact factor: 3.922

Review 6.  Population-based mechanistic prediction of oral drug absorption.

Authors:  Masoud Jamei; David Turner; Jiansong Yang; Sibylle Neuhoff; Sebastian Polak; Amin Rostami-Hodjegan; Geoffrey Tucker
Journal:  AAPS J       Date:  2009-04-21       Impact factor: 4.009

7.  Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.

Authors:  Takao Watanabe; Hiroyuki Kusuhara; Kazuya Maeda; Hiroshi Kanamaru; Yoshikazu Saito; Zhuohan Hu; Yuichi Sugiyama
Journal:  Drug Metab Dispos       Date:  2009-10-29       Impact factor: 3.922

8.  Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.

Authors:  Agnès Poirier; Christoph Funk; Jean-Michel Scherrmann; Thierry Lavé
Journal:  Mol Pharm       Date:  2009 Nov-Dec       Impact factor: 4.939

9.  Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.

Authors:  Masahiro Tsuda; Tomohiro Terada; Tomoyuki Mizuno; Toshiya Katsura; Jin Shimakura; Ken-ichi Inui
Journal:  Mol Pharmacol       Date:  2009-03-30       Impact factor: 4.436

Review 10.  In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney.

Authors:  Hiroyuki Kusuhara; Yuichi Sugiyama
Journal:  Drug Metab Pharmacokinet       Date:  2009       Impact factor: 3.614
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  50 in total

1.  P-Glycoprotein Transport of Neurotoxic Pesticides.

Authors:  Sarah E Lacher; Kasse Skagen; Joachim Veit; Rachel Dalton; Erica L Woodahl
Journal:  J Pharmacol Exp Ther       Date:  2015-08-13       Impact factor: 4.030

2.  Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Authors:  Yi-An Bi; Renato J Scialis; Sarah Lazzaro; Sumathy Mathialagan; Emi Kimoto; Julie Keefer; Hui Zhang; Anna M Vildhede; Chester Costales; A David Rodrigues; Larry M Tremaine; Manthena V S Varma
Journal:  AAPS J       Date:  2017-02-10       Impact factor: 4.009

Review 3.  Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.

Authors:  Daniel Scotcher; Christopher Jones; Maria Posada; Amin Rostami-Hodjegan; Aleksandra Galetin
Journal:  AAPS J       Date:  2016-06-30       Impact factor: 4.009

4.  Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs).

Authors:  Peng Duan; Ping Zhao; Lei Zhang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-08       Impact factor: 2.441

5.  A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions.

Authors:  Takashi Yoshikado; Kazuya Maeda; Sawako Furihata; Hanano Terashima; Takeshi Nakayama; Keiko Ishigame; Kazunobu Tsunemoto; Hiroyuki Kusuhara; Ken-Ichi Furihata; Yuichi Sugiyama
Journal:  Pharm Res       Date:  2017-05-08       Impact factor: 4.200

6.  Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.

Authors:  Yingying Guo; Xiaoyan Chu; Neil J Parrott; Kim L R Brouwer; Vicky Hsu; Swati Nagar; Pär Matsson; Pradeep Sharma; Jan Snoeys; Yuichi Sugiyama; Daniel Tatosian; Jashvant D Unadkat; Shiew-Mei Huang; Aleksandra Galetin
Journal:  Clin Pharmacol Ther       Date:  2018-09-12       Impact factor: 6.875

7.  Characterization of the transmembrane transport and absolute bioavailability of the HCV protease inhibitor danoprevir.

Authors:  Barbara J Brennan; Agnès Poirier; Sebastian Moreira; Peter N Morcos; Petra Goelzer; Renée Portmann; Jiney Asthappan; Christoph Funk; Patrick F Smith
Journal:  Clin Pharmacokinet       Date:  2015-05       Impact factor: 6.447

8.  Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat.

Authors:  Sarah E Lacher; Julia N Gremaud; Kasse Skagen; Emily Steed; Rachel Dalton; Kent D Sugden; Fernando Cardozo-Pelaez; Catherine M T Sherwin; Erica L Woodahl
Journal:  J Pharmacol Exp Ther       Date:  2013-12-02       Impact factor: 4.030

Review 9.  Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.

Authors:  Daniel Scotcher; Christopher Jones; Maria Posada; Aleksandra Galetin; Amin Rostami-Hodjegan
Journal:  AAPS J       Date:  2016-08-09       Impact factor: 4.009

Review 10.  Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.

Authors:  Rui Li; Hugh A Barton; Manthena V Varma
Journal:  Clin Pharmacokinet       Date:  2014-08       Impact factor: 6.447
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