Literature DB >> 23084821

Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites.

Souvik Bhattacharjee1, Robert V Stahelin, Kasturi Haldar.   

Abstract

Blood stage malaria parasites target a 'secretome' of hundreds of proteins including virulence determinants containing a host (cell) targeting (HT) signal, to human erythrocytes. Recent studies reveal that the export mechanism is due to the HT signal binding to the lipid phosphatidylinositol-3-phosphate [PI(3)P] in the parasite endoplasmic reticulum (ER). An aspartic protease plasmepsin V which cleaves a specialized form of the HT signal was previously thought to be the export mechanism, but is now recognized as a dedicated peptidase that cleaves the signal anchor subsequent to PI(3)P binding. We discuss a model of PI(3)P-dependent targeting and PI(3)P biology of a major human pathogen. Published by Elsevier Ltd.

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Year:  2012        PMID： 23084821      PMCID： PMC3501602          DOI： 10.1016/j.pt.2012.09.004

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  33 in total

1.  Cooperative domains define a unique host cell-targeting signal in Plasmodium falciparum-infected erythrocytes.

Authors:  Carlos Lopez-Estraño; Souvik Bhattacharjee; Travis Harrison; Kasturi Haldar
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-26       Impact factor: 11.205

2.  A host-targeting signal in virulence proteins reveals a secretome in malarial infection.

Authors:  N Luisa Hiller; Souvik Bhattacharjee; Christiaan van Ooij; Konstantinos Liolios; Travis Harrison; Carlos Lopez-Estraño; Kasturi Haldar
Journal:  Science       Date:  2004-12-10       Impact factor: 47.728

Review 3.  Protein transport and trafficking in Plasmodium falciparum-infected erythrocytes.

Authors:  J M Przyborski; M Lanzer
Journal:  Parasitology       Date:  2005-04       Impact factor: 3.234

4.  A membrane network for nutrient import in red cells infected with the malaria parasite.

Authors:  S A Lauer; P K Rathod; N Ghori; K Haldar
Journal:  Science       Date:  1997-05-16       Impact factor: 47.728

5.  Targeting malaria virulence and remodeling proteins to the host erythrocyte.

Authors:  Matthias Marti; Robert T Good; Melanie Rug; Ellen Knuepfer; Alan F Cowman
Journal:  Science       Date:  2004-12-10       Impact factor: 47.728

Review 6.  The pathogenic basis of malaria.

Authors:  Louis H Miller; Dror I Baruch; Kevin Marsh; Ogobara K Doumbo
Journal:  Nature       Date:  2002-02-07       Impact factor: 49.962

Review 7.  The apicoplast: a review of the derived plastid of apicomplexan parasites.

Authors:  Ross F Waller; Geoffrey I McFadden
Journal:  Curr Issues Mol Biol       Date:  2005-01       Impact factor: 2.081

8.  Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch.

Authors:  Stephanie A Lee; Rosemary Eyeson; Matthew L Cheever; Jinming Geng; Vladislav V Verkhusha; Christopher Burd; Michael Overduin; Tatiana G Kutateladze
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-02       Impact factor: 11.205

9.  Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites.

Authors:  Tobias J Sargeant; Matthias Marti; Elisabet Caler; Jane M Carlton; Ken Simpson; Terence P Speed; Alan F Cowman
Journal:  Genome Biol       Date:  2006-02-20       Impact factor: 13.583

10.  A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells.

Authors:  Brian M Cooke; Donna W Buckingham; Fiona K Glenister; Kate M Fernandez; Lawrence H Bannister; Matthias Marti; Narla Mohandas; Ross L Coppel
Journal:  J Cell Biol       Date:  2006-03-06       Impact factor: 10.539
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  8 in total

Review 1.  Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.

Authors:  Benjamin Blasco; Didier Leroy; David A Fidock
Journal:  Nat Med       Date:  2017-08-04       Impact factor: 53.440

Review 2.  Why do malaria parasites increase host erythrocyte permeability?

Authors:  Sanjay A Desai
Journal:  Trends Parasitol       Date:  2014-02-05

3.  Non-ribosomal insights into ribosomal P2 protein in Plasmodium falciparum-infected erythrocytes.

Authors:  Sudipta Das; Bhaskar Roy; Saswata Chakrabarty
Journal:  Microbiologyopen       Date:  2021-08       Impact factor: 3.139

Review 4.  The systematic analysis of protein-lipid interactions comes of age.

Authors:  Antoine-Emmanuel Saliba; Ivana Vonkova; Anne-Claude Gavin
Journal:  Nat Rev Mol Cell Biol       Date:  2015-10-28       Impact factor: 94.444

5.  Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).

Authors:  Sandra Gomez; Laura Adalid-Peralta; Hector Palafox-Fonseca; Vito Adrian Cantu-Robles; Xavier Soberón; Edda Sciutto; Gladis Fragoso; Raúl J Bobes; Juan P Laclette; Luis del Pozo Yauner; Adrián Ochoa-Leyva
Journal:  Sci Rep       Date:  2015-05-19       Impact factor: 4.379

6.  A novel, sequencing-free strategy for the functional characterization of Taenia solium proteomic fingerprint.

Authors:  Sandra Gomez-Fuentes; Sarah Hernández-de la Fuente; Valeria Morales-Ruiz; Dina López-Recinos; Adrián Guevara-Salinas; María Cristina Parada-Colin; Clara Espitia; Adrián Ochoa-Leyva; Filiberto Sánchez; Nelly Villalobos; Asiel Arce-Sillas; Marisela Hernández; Silvia Ivonne Mora; Gladis Fragoso; Edda Sciutto; Laura Adalid-Peralta
Journal:  PLoS Negl Trop Dis       Date:  2021-02-18

7.  The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions.

Authors:  Joachim M Matz; Christian Goosmann; Volker Brinkmann; Josephine Grützke; Alyssa Ingmundson; Kai Matuschewski; Taco W A Kooij
Journal:  Sci Rep       Date:  2015-07-29       Impact factor: 4.379

8.  Vacuolar protein sorting mechanisms in apicomplexan parasites.

Authors:  Elena Jimenez-Ruiz; Juliette Morlon-Guyot; Wassim Daher; Markus Meissner
Journal:  Mol Biochem Parasitol       Date:  2016-02-01       Impact factor: 1.759
  8 in total

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