OBJECTIVES: To evaluate the cytokine response pattern in Inuit in Greenland in relation to age, gender, body mass index (BMI), Mycobacterium tuberculosis infection (MTI), and otitis media (OM) to assess whether Inuit may have signs of impaired immune responsiveness to infection. METHODS: A cross-sectional health assessment was conducted among inhabitants of Maniitsoq, West Greenland, in 2009, and several health outcomes were measured. The prevalence of MTI, overweight, and obesity was assessed among 263 school children and 137 adults, and OM was assessed among the children. Cytokine responses were measured in whole blood cultures after stimulation with phytohemagglutinin or purified protein derivative (PPD). Associations between cytokine concentrations, age, gender, BMI, MTI, and OM were estimated by linear regression. RESULTS: Adults had generally higher cytokine concentrations than children. Children with MTI had 2.7 times higher interleukin (IL)-10 concentrations than those without (P = 0.01), and girls had 80% higher IL-10 than boys (P < 0.01) after phytohemagglutinin stimulation. Interferon (IFN)γ and tumor necrosis factor (TNF) concentrations were strongly elevated among children (P(IFNγ) < 0.001 and P(TNF) < 0.001) and adults (P(IFNγ) < 0.001 and P(TNF) <0.01) with MTI compared to those without after PPD stimulation. Adult women had significantly lower IFNγ (P = 0.03) and TNF (P = 0.04) concentrations than men. TNF was positively correlated with BMI in children (P = 0.01), and IL-10 was positively correlated with BMI in adults (P = 0.0004) after PPD stimulation. CONCLUSION: We found cytokine patterns similar to those reported from other immune competent study populations. Therefore, the study does not support the suggestion that Inuit may have impaired immune reactivity to infection.
OBJECTIVES: To evaluate the cytokine response pattern in Inuit in Greenland in relation to age, gender, body mass index (BMI), Mycobacterium tuberculosis infection (MTI), and otitis media (OM) to assess whether Inuit may have signs of impaired immune responsiveness to infection. METHODS: A cross-sectional health assessment was conducted among inhabitants of Maniitsoq, West Greenland, in 2009, and several health outcomes were measured. The prevalence of MTI, overweight, and obesity was assessed among 263 school children and 137 adults, and OM was assessed among the children. Cytokine responses were measured in whole blood cultures after stimulation with phytohemagglutinin or purified protein derivative (PPD). Associations between cytokine concentrations, age, gender, BMI, MTI, and OM were estimated by linear regression. RESULTS: Adults had generally higher cytokine concentrations than children. Children with MTI had 2.7 times higher interleukin (IL)-10 concentrations than those without (P = 0.01), and girls had 80% higher IL-10 than boys (P < 0.01) after phytohemagglutinin stimulation. Interferon (IFN)γ and tumor necrosis factor (TNF) concentrations were strongly elevated among children (P(IFNγ) < 0.001 and P(TNF) < 0.001) and adults (P(IFNγ) < 0.001 and P(TNF) <0.01) with MTI compared to those without after PPD stimulation. Adult women had significantly lower IFNγ (P = 0.03) and TNF (P = 0.04) concentrations than men. TNF was positively correlated with BMI in children (P = 0.01), and IL-10 was positively correlated with BMI in adults (P = 0.0004) after PPD stimulation. CONCLUSION: We found cytokine patterns similar to those reported from other immune competent study populations. Therefore, the study does not support the suggestion that Inuit may have impaired immune reactivity to infection.
Authors: Rob Ter Horst; Martin Jaeger; Sanne P Smeekens; Marije Oosting; Morris A Swertz; Yang Li; Vinod Kumar; Dimitri A Diavatopoulos; Anne F M Jansen; Heidi Lemmers; Helga Toenhake-Dijkstra; Antonius E van Herwaarden; Matthijs Janssen; Renate G van der Molen; Irma Joosten; Fred C G J Sweep; Johannes W Smit; Romana T Netea-Maier; Mieke M J F Koenders; Ramnik J Xavier; Jos W M van der Meer; Charles A Dinarello; Norman Pavelka; Cisca Wijmenga; Richard A Notebaart; Leo A B Joosten; Mihai G Netea Journal: Cell Date: 2016-11-03 Impact factor: 41.582
Authors: Tatiana Pereira da Silva; Carmem Beatriz Wagner Giacoia-Gripp; Carolina A Schmaltz; Flavia Marinho Sant'Anna; Maria Helena Saad; Juliana Arruda de Matos; Julio Castro Alves de Lima E Silva; Valeria Cavalcanti Rolla; Mariza Gonçalves Morgado Journal: BMC Infect Dis Date: 2017-09-06 Impact factor: 3.090
Authors: Simon G Kimuda; Angela Nalwoga; Jonathan Levin; Kees L M C Franken; Tom H M Ottenhoff; Alison M Elliott; Stephen Cose; Irene Andia-Biraro Journal: J Immunol Res Date: 2017-02-01 Impact factor: 4.818
Authors: M Weckmann; D Thiele; L Liboschik; T Bahmer; M Pech; A-M Dittrich; O Fuchs; C Happle; B Schaub; I Ricklefs; K F Rabe; E von Mutius; G Hansen; I R König; M V Kopp Journal: Clin Exp Immunol Date: 2020-12-15 Impact factor: 5.732