Literature DB >> 23065727

Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α.

Dennis L Buckley1, Jeffrey L Gustafson, Inge Van Molle, Anke G Roth, Hyun Seop Tae, Peter C Gareiss, William L Jorgensen, Alessio Ciulli, Craig M Crews.   

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Year:  2012        PMID： 23065727      PMCID： PMC3519281          DOI： 10.1002/anie.201206231

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  31 in total

1.  Structure of the stapled p53 peptide bound to Mdm2.

Authors:  Sohee Baek; Peter S Kutchukian; Gregory L Verdine; Robert Huber; Tad A Holak; Ki Won Lee; Grzegorz M Popowicz
Journal:  J Am Chem Soc       Date:  2011-12-14       Impact factor: 15.419

2.  Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand.

Authors:  Xinyi Huang
Journal:  J Biomol Screen       Date:  2003-02

3.  Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions.

Authors:  Tim Geppert; Stefanie Bauer; Jan A Hiss; Elea Conrad; Michael Reutlinger; Petra Schneider; Martin Weisel; Bernhard Pfeiffer; Karl-Heinz Altmann; Zoe Waibler; Gisbert Schneider
Journal:  Angew Chem Int Ed Engl       Date:  2011-11-16       Impact factor: 15.336

Review 4.  Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics.

Authors:  Rob M J Liskamp; Dirk T S Rijkers; John A W Kruijtzer; Johan Kemmink
Journal:  Chembiochem       Date:  2011-07-12       Impact factor: 3.164

5.  Structural conservation of druggable hot spots in protein-protein interfaces.

Authors:  Dima Kozakov; David R Hall; Gwo-Yu Chuang; Regina Cencic; Ryan Brenke; Laurie E Grove; Dmitri Beglov; Jerry Pelletier; Adrian Whitty; Sandor Vajda
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-01       Impact factor: 11.205

6.  Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.

Authors:  Melissa D Boersma; Holly S Haase; Kimberly J Peterson-Kaufman; Erinna F Lee; Oliver B Clarke; Peter M Colman; Brian J Smith; W Seth Horne; W Douglas Fairlie; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2011-12-08       Impact factor: 15.419

7.  A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

Authors:  Akane Kawamura; Alexander Wolf; Dante Rotili; Mikael Altun; Roman Fischer; Ivanhoe K H Leung; Mukram M Mackeen; Ya-Min Tian; Peter J Ratcliffe; Antonello Mai; Benedikt M Kessler; Christopher J Schofield
Journal:  Chem Biol       Date:  2011-05-27

8.  Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Authors:  Wai-Ching Hon; Michael I Wilson; Karl Harlos; Timothy D W Claridge; Christopher J Schofield; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe; David I Stuart; E Yvonne Jones
Journal:  Nature       Date:  2002-06-05       Impact factor: 49.962

9.  In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.

Authors:  Lyubomir T Vassilev; Binh T Vu; Bradford Graves; Daisy Carvajal; Frank Podlaski; Zoran Filipovic; Norman Kong; Ursula Kammlott; Christine Lukacs; Christian Klein; Nader Fotouhi; Emily A Liu
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

10.  Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction.

Authors:  Dennis L Buckley; Inge Van Molle; Peter C Gareiss; Hyun Seop Tae; Julien Michel; Devin J Noblin; William L Jorgensen; Alessio Ciulli; Craig M Crews
Journal:  J Am Chem Soc       Date:  2012-02-27       Impact factor: 15.419
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  81 in total

Review 1.  Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

Authors:  Michelle R Arkin; Yinyan Tang; James A Wells
Journal:  Chem Biol       Date:  2014-09-18

2.  Nature Biotechnology's academic spinouts of 2013.

Authors:  Aaron Bouchie; Malorye Allison; Sarah Webb; Laura DeFrancesco
Journal:  Nat Biotechnol       Date:  2014-03       Impact factor: 54.908

3.  Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation.

Authors:  Tanpreet Kaur; Arya Menon; Amanda L Garner
Journal:  Eur J Med Chem       Date:  2019-01-31       Impact factor: 6.514

4.  Exploiting Ubiquitin Ligases for Induced Target Degradation as an Antiviral Strategy.

Authors:  Rati Verma
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.

Authors:  George M Burslem; Blake E Smith; Ashton C Lai; Saul Jaime-Figueroa; Daniel C McQuaid; Daniel P Bondeson; Momar Toure; Hanqing Dong; Yimin Qian; Jing Wang; Andrew P Crew; John Hines; Craig M Crews
Journal:  Cell Chem Biol       Date:  2017-11-09       Impact factor: 8.116

6.  Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

Authors:  Daniel P Bondeson; Blake E Smith; George M Burslem; Alexandru D Buhimschi; John Hines; Saul Jaime-Figueroa; Jing Wang; Brian D Hamman; Alexey Ishchenko; Craig M Crews
Journal:  Cell Chem Biol       Date:  2017-11-09       Impact factor: 8.116

Review 7.  PROteolysis TArgeting Chimeras (PROTACs) - Past, present and future.

Authors:  Mariell Pettersson; Craig M Crews
Journal:  Drug Discov Today Technol       Date:  2019-02-13

Review 8.  Emerging modes-of-action in drug discovery.

Authors:  Eric Valeur; Frank Narjes; Christian Ottmann; Alleyn T Plowright
Journal:  Medchemcomm       Date:  2019-06-25       Impact factor: 3.597

Review 9.  Induced protein degradation: an emerging drug discovery paradigm.

Authors:  Ashton C Lai; Craig M Crews
Journal:  Nat Rev Drug Discov       Date:  2016-11-25       Impact factor: 84.694

10.  Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

Authors:  Ashton C Lai; Momar Toure; Doris Hellerschmied; Jemilat Salami; Saul Jaime-Figueroa; Eunhwa Ko; John Hines; Craig M Crews
Journal:  Angew Chem Int Ed Engl       Date:  2015-11-23       Impact factor: 15.336
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