PURPOSE: We recently reported an increasing risk over time of hospitalization among Medicare participants after undergoing an initial prostate biopsy. Less is known about the relative risks of repeat prostate biopsies, which are frequently performed in prostate cancer screening and in active surveillance programs. We determined whether repeat biopsies are associated with an increased risk of hospitalization compared to the initial biopsy. MATERIALS AND METHODS: Using SEER (Surveillance, Epidemiology and End Results)-Medicare linked data from 1991 to 2007 we identified 13,883 men who underwent a single prostate biopsy and 3,640 who had multiple biopsies. The 30-day hospitalization rates were compared between these groups, and with a randomly selected control population of 134,977. ICD-9 codes were then used to examine the frequency of serious infectious and noninfectious urological complications as the primary diagnosis for hospital admissions. RESULTS: Initial and repeat biopsies were associated with a significantly increased risk of hospitalization within a 30-day period compared to randomly selected controls (p <0.0001). However, the repeat biopsy session was not associated with a greater risk of infectious (OR 0.81, 95% 0.49-1.32, p = 0.39) or serious noninfectious urological complications (OR 0.94, 95% CI 0.54-1.62, p = 0.82) compared to the initial biopsy. CONCLUSIONS: Each biopsy was associated with a significant risk of complications compared to randomly selected controls. However, the repeat biopsy procedure itself was not associated with a greater risk of serious complications requiring hospital admission compared to the initial biopsy.
PURPOSE: We recently reported an increasing risk over time of hospitalization among Medicare participants after undergoing an initial prostate biopsy. Less is known about the relative risks of repeat prostate biopsies, which are frequently performed in prostate cancer screening and in active surveillance programs. We determined whether repeat biopsies are associated with an increased risk of hospitalization compared to the initial biopsy. MATERIALS AND METHODS: Using SEER (Surveillance, Epidemiology and End Results)-Medicare linked data from 1991 to 2007 we identified 13,883 men who underwent a single prostate biopsy and 3,640 who had multiple biopsies. The 30-day hospitalization rates were compared between these groups, and with a randomly selected control population of 134,977. ICD-9 codes were then used to examine the frequency of serious infectious and noninfectious urological complications as the primary diagnosis for hospital admissions. RESULTS: Initial and repeat biopsies were associated with a significantly increased risk of hospitalization within a 30-day period compared to randomly selected controls (p <0.0001). However, the repeat biopsy session was not associated with a greater risk of infectious (OR 0.81, 95% 0.49-1.32, p = 0.39) or serious noninfectious urological complications (OR 0.94, 95% CI 0.54-1.62, p = 0.82) compared to the initial biopsy. CONCLUSIONS: Each biopsy was associated with a significant risk of complications compared to randomly selected controls. However, the repeat biopsy procedure itself was not associated with a greater risk of serious complications requiring hospital admission compared to the initial biopsy.
Authors: George G Zhanel; Tamiko L Hisanaga; Nancy M Laing; Melanie R DeCorby; Kim A Nichol; Lorraine P Palatnik; Jack Johnson; Ayman Noreddin; Godfrey K M Harding; Lindsay E Nicolle; Daryl J Hoban Journal: Int J Antimicrob Agents Date: 2005-11 Impact factor: 5.283
Authors: B Djavan; M Waldert; A Zlotta; P Dobronski; C Seitz; M Remzi; A Borkowski; C Schulman; M Marberger Journal: J Urol Date: 2001-09 Impact factor: 7.450
Authors: Fritz H Schröder; Jonas Hugosson; Monique J Roobol; Teuvo L J Tammela; Stefano Ciatto; Vera Nelen; Maciej Kwiatkowski; Marcos Lujan; Hans Lilja; Marco Zappa; Louis J Denis; Franz Recker; Alvaro Páez; Liisa Määttänen; Chris H Bangma; Gunnar Aus; Sigrid Carlsson; Arnauld Villers; Xavier Rebillard; Theodorus van der Kwast; Paula M Kujala; Bert G Blijenberg; Ulf-Hakan Stenman; Andreas Huber; Kimmo Taari; Matti Hakama; Sue M Moss; Harry J de Koning; Anssi Auvinen Journal: N Engl J Med Date: 2012-03-15 Impact factor: 91.245
Authors: Michael A Liss; Alexandra Chang; Rosanne Santos; Amy Nakama-Peeples; Ellena M Peterson; Kathryn Osann; John Billimek; Richard J Szabo; Atreya Dash Journal: J Urol Date: 2011-02-22 Impact factor: 7.450
Authors: Sigrid V Carlsson; Erik Holmberg; Sue M Moss; Monique J Roobol; Fritz H Schröder; Teuvo L J Tammela; Gunnar Aus; Anssi P Auvinen; Jonas Hugosson Journal: BJU Int Date: 2010-10-15 Impact factor: 5.588
Authors: Robert K Nam; Refik Saskin; Yuna Lee; Ying Liu; Calvin Law; Laurence H Klotz; D Andrew Loblaw; John Trachtenberg; Aleksandra Stanimirovic; Andrew E Simor; Arun Seth; David R Urbach; Steven A Narod Journal: J Urol Date: 2010-01-20 Impact factor: 7.450
Authors: Florian M E Wagenlehner; Adrian Pilatz; Przemyslaw Waliszewski; Wolfgang Weidner; Truls E Bjerklund Johansen Journal: Nat Rev Urol Date: 2014-01-14 Impact factor: 14.432
Authors: Gregory S Merrick; Robert W Galbreath; Abbey Bennett; Wayne M Butler; Edward Amamovich Journal: World J Urol Date: 2016-11-29 Impact factor: 4.226
Authors: A Leone; B Gershman; K Rotker; C Butler; J Fantasia; A Miller; A Afiadata; A Amin; A Zhou; Z Jiang; T Sebo; A Mega; S Schiff; G Pareek; D Golijanin; J Yates; R J Karnes; J Renzulli Journal: Prostate Cancer Prostatic Dis Date: 2015-11-17 Impact factor: 5.554
Authors: Leslie A Ynalvez; Christopher D Kosarek; Preston S Kerr; Ali M Mahmoud; Eduardo J Eyzaguirre; Eduardo Orihuela; Joseph N Sonstein; Stephen B Williams Journal: Int Urol Nephrol Date: 2017-10-24 Impact factor: 2.370
Authors: Abhinav Sidana; Matthew J Watson; Arvin K George; Ardeshir R Rastinehad; Srinivas Vourganti; Soroush Rais-Bahrami; Akhil Muthigi; Mahir Maruf; Jennifer B Gordetsky; Jeffrey W Nix; Maria J Merino; Baris Turkbey; Peter L Choyke; Bradford J Wood; Peter A Pinto Journal: Urol Oncol Date: 2018-05-10 Impact factor: 3.498