Literature DB >> 23051696

Atomic force microscopy captures folded ribosome bound nascent chains.

Anna Loksztejn1, Zackary Scholl, Piotr E Marszalek.   

Abstract

Direct visualization of co-translational folding of nascent polypeptide chains is challenging. Here we present, for the first time, AFM images of large protein constructs based on the membrane binding domain of ankyrin-R, complexed with the ribosome. The characteristic "horse-shoe" shape of ankyrin-R emerging from the ribosome was captured.

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Year:  2012        PMID： 23051696      PMCID： PMC3804001          DOI： 10.1039/c2cc35551e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

1.  The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.

Authors:  N Ban; P Nissen; J Hansen; P B Moore; T A Steitz
Journal:  Science       Date:  2000-08-11       Impact factor: 47.728

2.  Three-dimensional structures of translating ribosomes by Cryo-EM.

Authors:  Robert J C Gilbert; Paola Fucini; Sean Connell; Stephen D Fuller; Knud H Nierhaus; Carol V Robinson; Christopher M Dobson; David I Stuart
Journal:  Mol Cell       Date:  2004-04-09       Impact factor: 17.970

3.  Protein folding in the cell: reshaping the folding funnel.

Authors:  Patricia L Clark
Journal:  Trends Biochem Sci       Date:  2004-10       Impact factor: 13.807

4.  Imaging the substructure of antibodies with tapping-mode AFM in air: the importance of a water layer on mica.

Authors:  N H Thomson
Journal:  J Microsc       Date:  2005-03       Impact factor: 1.758

5.  Homogeneous stalled ribosome nascent chain complexes produced in vivo or in vitro.

Authors:  Michael S Evans; Krastyu G Ugrinov; Marc-André Frese; Patricia L Clark
Journal:  Nat Methods       Date:  2005-10       Impact factor: 28.547

6.  The substructure of immunoglobulin G resolved to 25 kDa using amplitude modulation AFM in air.

Authors:  Neil H Thomson
Journal:  Ultramicroscopy       Date:  2005-07-13       Impact factor: 2.689

7.  Immunoglobulin-like modules from titin I-band: extensible components of muscle elasticity.

Authors:  S Improta; A S Politou; A Pastore
Journal:  Structure       Date:  1996-03-15       Impact factor: 5.006

8.  Mechanical studies of single ribosome/mRNA complexes.

Authors:  Francesco Vanzi; Yasuharu Takagi; Henry Shuman; Barry S Cooperman; Yale E Goldman
Journal:  Biophys J       Date:  2005-06-10       Impact factor: 4.033

9.  The ribosome modulates nascent protein folding.

Authors:  Christian M Kaiser; Daniel H Goldman; John D Chodera; Ignacio Tinoco; Carlos Bustamante
Journal:  Science       Date:  2011-12-23       Impact factor: 47.728

10.  Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation.

Authors:  H Lu; B Isralewitz; A Krammer; V Vogel; K Schulten
Journal:  Biophys J       Date:  1998-08       Impact factor: 4.033
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  2 in total

Review 1.  Unraveling co-translational protein folding: Concepts and methods.

Authors:  Anton A Komar
Journal:  Methods       Date:  2017-12-06       Impact factor: 3.608

Review 2.  Protein folding on the ribosome studied using NMR spectroscopy.

Authors:  Christopher A Waudby; Hélène Launay; Lisa D Cabrita; John Christodoulou
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2013-07-27       Impact factor: 9.795
  2 in total

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