Literature DB >> 23042634

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.

Chinmay Y Majmudar1, Jonas W Højfeldt, Carl J Arevang, William C Pomerantz, Jessica K Gagnon, Pamela J Schultz, Laura C Cesa, Conor H Doss, Steven P Rowe, Victor Vásquez, Giselle Tamayo-Castillo, Tomasz Cierpicki, Charles L Brooks, David H Sherman, Anna K Mapp.   

Abstract

Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300. These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23042634      PMCID： PMC3711073          DOI： 10.1002/anie.201206815

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  54 in total

1.  Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain.

Authors:  Stacey E Rutledge; Heather M Volkman; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2003-11-26       Impact factor: 15.419

2.  Linking transcriptional mediators via the GACKIX domain super family.

Authors:  Maria Novatchkova; Frank Eisenhaber
Journal:  Curr Biol       Date:  2004-01-20       Impact factor: 10.834

Review 3.  Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

Authors:  Michelle R Arkin; James A Wells
Journal:  Nat Rev Drug Discov       Date:  2004-04       Impact factor: 84.694

4.  A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.

Authors:  Hiroki Shimogawa; Youngjoo Kwon; Qian Mao; Yoshinori Kawazoe; Yongmun Choi; Shinichi Asada; Hideo Kigoshi; Motonari Uesugi
Journal:  J Am Chem Soc       Date:  2004-03-24       Impact factor: 15.419

5.  Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb.

Authors:  Tsaffrir Zor; Roberto N De Guzman; H Jane Dyson; Peter E Wright
Journal:  J Mol Biol       Date:  2004-03-26       Impact factor: 5.469

Review 6.  Transcriptional activation by recruitment.

Authors:  M Ptashne; A Gann
Journal:  Nature       Date:  1997-04-10       Impact factor: 49.962

7.  Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB.

Authors:  Kathleen M Campbell; Kevin J Lumb
Journal:  Biochemistry       Date:  2002-11-26       Impact factor: 3.162

Review 8.  Pharmaceutically relevant metabolites from lichens.

Authors:  K Müller
Journal:  Appl Microbiol Biotechnol       Date:  2001-07       Impact factor: 4.813

9.  Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.

Authors:  J V Frangioni; L M LaRiccia; L C Cantley; M R Montminy
Journal:  Nat Biotechnol       Date:  2000-10       Impact factor: 54.908

10.  Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain.

Authors:  Natalie K Goto; Tsaffrir Zor; Maria Martinez-Yamout; H Jane Dyson; Peter E Wright
Journal:  J Biol Chem       Date:  2002-08-29       Impact factor: 5.157
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  18 in total

Review 1.  Protein lysine acetylation by p300/CBP.

Authors:  Beverley M Dancy; Philip A Cole
Journal:  Chem Rev       Date:  2015-01-16       Impact factor: 60.622

2.  Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.

Authors:  Ningkun Wang; Jean M Lodge; Carol A Fierke; Anna K Mapp
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-21       Impact factor: 11.205

Review 3.  The role of HTS in drug discovery at the University of Michigan.

Authors:  Martha J Larsen; Scott D Larsen; Andrew Fribley; Jolanta Grembecka; Kristoff Homan; Anna Mapp; Andrew Haak; Zaneta Nikolovska-Coleska; Jeanne A Stuckey; Duxin Sun; David H Sherman
Journal:  Comb Chem High Throughput Screen       Date:  2014-03       Impact factor: 1.339

4.  Targeting Unoccupied Surfaces on Protein-Protein Interfaces.

Authors:  David Rooklin; Ashley E Modell; Haotian Li; Viktoriya Berdan; Paramjit S Arora; Yingkai Zhang
Journal:  J Am Chem Soc       Date:  2017-08-04       Impact factor: 15.419

5.  From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.

Authors:  Rachel Pricer; Jason E Gestwicki; Anna K Mapp
Journal:  Acc Chem Res       Date:  2017-03-21       Impact factor: 22.384

6.  Dual Labeling of the CBP/p300 KIX Domain for 19 F NMR Leads to Identification of a New Small-Molecule Binding Site.

Authors:  Clifford T Gee; Keith E Arntson; Edward J Koleski; Rachel Lynn Staebell; William C K Pomerantz
Journal:  Chembiochem       Date:  2018-04-06       Impact factor: 3.164

7.  Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription.

Authors:  Fuchun Xie; Bingbing X Li; Candice Broussard; Xiangshu Xiao
Journal:  Bioorg Med Chem Lett       Date:  2013-07-31       Impact factor: 2.823

8.  Ordering a dynamic protein via a small-molecule stabilizer.

Authors:  Ningkun Wang; Chinmay Y Majmudar; William C Pomerantz; Jessica K Gagnon; Jack D Sadowsky; Jennifer L Meagher; Taylor K Johnson; Jeanne A Stuckey; Charles L Brooks; James A Wells; Anna K Mapp
Journal:  J Am Chem Soc       Date:  2013-02-22       Impact factor: 15.419

9.  Targeting transcription is no longer a quixotic quest.

Authors:  Anna K Mapp; Rachel Pricer; Steven Sturlis
Journal:  Nat Chem Biol       Date:  2015-12       Impact factor: 15.040

10.  Prepaying the entropic cost for allosteric regulation in KIX.

Authors:  Sean M Law; Jessica K Gagnon; Anna K Mapp; Charles L Brooks
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-07       Impact factor: 11.205
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