Literature DB >> 23036599

Stem cells and modeling of autism spectrum disorders.

Beatriz C G Freitas1, Cleber A Trujillo1, Cassiano Carromeu1, Marianna Yusupova1, Roberto H Herai1, Alysson R Muotri2.   

Abstract

Human neurons, generated from reprogrammed somatic cells isolated from live patients, bring a new perspective on the understanding of Autism Spectrum Disorders (ASD). The new technology can nicely complement other models for basic research and the development of therapeutic compounds aiming to revert or ameliorate the condition. Here, we discuss recent advances on the use of stem cells and other models to study ASDs, as well as their limitations, implications and future perspectives.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Angelman syndrome; Animal model; Autism spectrum disorders; Fragile X syndrome; Genomic editing; Induced pluripotent stem cells; Rett syndrome; Stem cells; Timothy syndrome

Mesh：

Year:  2012        PMID： 23036599      PMCID： PMC3568448          DOI： 10.1016/j.expneurol.2012.09.017

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  151 in total

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Authors:  Sabrina C Desbordes; Dimitris G Placantonakis; Anthony Ciro; Nicholas D Socci; Gabsang Lee; Hakim Djaballah; Lorenz Studer
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2.  Mildly impaired water maze performance in male Fmr1 knockout mice.

Authors:  R D'Hooge; G Nagels; F Franck; C E Bakker; E Reyniers; K Storm; R F Kooy; B A Oostra; P J Willems; P P De Deyn
Journal:  Neuroscience       Date:  1997-01       Impact factor: 3.590

3.  Brief report: the medical care of adults with autism spectrum disorders: identifying the needs.

Authors:  Mary Beth Bruder; Gerard Kerins; Cynthia Mazzarella; Jessica Sims; Neil Stein
Journal:  J Autism Dev Disord       Date:  2012-11

4.  Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse.

Authors:  Yann S Mineur; Frans Sluyter; Sanne de Wit; Ben A Oostra; Wim E Crusio
Journal:  Hippocampus       Date:  2002       Impact factor: 3.899

Review 5.  Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.

Authors:  Maria C Marchetto; Kristen J Brennand; Leah F Boyer; Fred H Gage
Journal:  Hum Mol Genet       Date:  2011-08-09       Impact factor: 6.150

6.  Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

Authors:  Elena D Nosyreva; Kimberly M Huber
Journal:  J Neurophysiol       Date:  2006-02-01       Impact factor: 2.714

7.  The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages.

Authors:  Cynthia Mills Schumann; Julia Hamstra; Beth L Goodlin-Jones; Linda J Lotspeich; Hower Kwon; Michael H Buonocore; Cathy R Lammers; Allan L Reiss; David G Amaral
Journal:  J Neurosci       Date:  2004-07-14       Impact factor: 6.167

8.  Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation.

Authors:  Garilyn M Jentarra; Shannon L Olfers; Stephen G Rice; Nishit Srivastava; Gregg E Homanics; Mary Blue; Sakkubai Naidu; Vinodh Narayanan
Journal:  BMC Neurosci       Date:  2010-02-17       Impact factor: 3.288

9.  Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.

Authors:  Joseph T Glessner; Kai Wang; Guiqing Cai; Olena Korvatska; Cecilia E Kim; Shawn Wood; Haitao Zhang; Annette Estes; Camille W Brune; Jonathan P Bradfield; Marcin Imielinski; Edward C Frackelton; Jennifer Reichert; Emily L Crawford; Jeffrey Munson; Patrick M A Sleiman; Rosetta Chiavacci; Kiran Annaiah; Kelly Thomas; Cuiping Hou; Wendy Glaberson; James Flory; Frederick Otieno; Maria Garris; Latha Soorya; Lambertus Klei; Joseph Piven; Kacie J Meyer; Evdokia Anagnostou; Takeshi Sakurai; Rachel M Game; Danielle S Rudd; Danielle Zurawiecki; Christopher J McDougle; Lea K Davis; Judith Miller; David J Posey; Shana Michaels; Alexander Kolevzon; Jeremy M Silverman; Raphael Bernier; Susan E Levy; Robert T Schultz; Geraldine Dawson; Thomas Owley; William M McMahon; Thomas H Wassink; John A Sweeney; John I Nurnberger; Hilary Coon; James S Sutcliffe; Nancy J Minshew; Struan F A Grant; Maja Bucan; Edwin H Cook; Joseph D Buxbaum; Bernie Devlin; Gerard D Schellenberg; Hakon Hakonarson
Journal:  Nature       Date:  2009-04-28       Impact factor: 49.962

10.  Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.

Authors:  Caitlyn H McNaughton; Jisook Moon; Myla S Strawderman; Kenneth N Maclean; Jeffrey Evans; Barbara J Strupp
Journal:  Behav Neurosci       Date:  2008-04       Impact factor: 1.912
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  7 in total

1.  Fibroblast sources: Where can we get them?

Authors:  I R Fernandes; F B Russo; G C Pignatari; M M Evangelinellis; S Tavolari; A R Muotri; P C B Beltrão-Braga
Journal:  Cytotechnology       Date:  2014-07-25       Impact factor: 2.058

Review 2.  Role of astrocyte-synapse interactions in CNS disorders.

Authors:  Elena Blanco-Suárez; Alison L M Caldwell; Nicola J Allen
Journal:  J Physiol       Date:  2016-08-08       Impact factor: 5.182

Review 3.  The Human Model: Changing Focus on Autism Research.

Authors:  Alysson Renato Muotri
Journal:  Biol Psychiatry       Date:  2015-03-17       Impact factor: 13.382

4.  Validation of reference genes for use in untreated bovine fibroblasts.

Authors:  T Toorani; P M Mackie; G F Mastromonaco
Journal:  Sci Rep       Date:  2021-05-13       Impact factor: 4.379

Review 5.  A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research.

Authors:  Sára Kálmán; Edit Hathy; János M Réthelyi
Journal:  Stem Cells Int       Date:  2015-12-29       Impact factor: 5.443

6.  Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.

Authors:  Maria C Marchetto; Haim Belinson; Yuan Tian; Beatriz C Freitas; Chen Fu; Krishna Vadodaria; Patricia Beltrao-Braga; Cleber A Trujillo; Ana P D Mendes; Krishnan Padmanabhan; Yanelli Nunez; Jing Ou; Himanish Ghosh; Rebecca Wright; Kristen Brennand; Karen Pierce; Lawrence Eichenfield; Tiziano Pramparo; Lisa Eyler; Cynthia C Barnes; Eric Courchesne; Daniel H Geschwind; Fred H Gage; Anthony Wynshaw-Boris; Alysson R Muotri
Journal:  Mol Psychiatry       Date:  2016-07-05       Impact factor: 15.992

Review 7.  Mental health dished up-the use of iPSC models in neuropsychiatric research.

Authors:  Rhiannon V McNeill; Georg C Ziegler; Franziska Radtke; Matthias Nieberler; Klaus-Peter Lesch; Sarah Kittel-Schneider
Journal:  J Neural Transm (Vienna)       Date:  2020-05-07       Impact factor: 3.575
  7 in total

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