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Literature DB >> 21828073

Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.

Maria C Marchetto¹, Kristen J Brennand, Leah F Boyer, Fred H Gage.

Abstract

The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.

Entities: Disease Species

Mesh：

Year: 2011 PMID： 21828073 PMCID： PMC4447776 DOI： 10.1093/hmg/ddr336

Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150

68 in total

1. A microfluidic culture platform for CNS axonal injury, regeneration and transport.

Authors: Anne M Taylor; Mathew Blurton-Jones; Seog Woo Rhee; David H Cribbs; Carl W Cotman; Noo Li Jeon
Journal: Nat Methods Date: 2005-08 Impact factor: 28.547

2. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Authors: Frank Soldner; Josée Laganière; Albert W Cheng; Dirk Hockemeyer; Qing Gao; Raaji Alagappan; Vikram Khurana; Lawrence I Golbe; Richard H Myers; Susan Lindquist; Lei Zhang; Dmitry Guschin; Lauren K Fong; B Joseph Vu; Xiangdong Meng; Fyodor D Urnov; Edward J Rebar; Philip D Gregory; H Steve Zhang; Rudolf Jaenisch
Journal: Cell Date: 2011-07-14 Impact factor: 41.582

3. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Authors: Makiko Nagai; Diane B Re; Tetsuya Nagata; Alcmène Chalazonitis; Thomas M Jessell; Hynek Wichterle; Serge Przedborski
Journal: Nat Neurosci Date: 2007-04-15 Impact factor: 24.884

4. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Authors: Avshalom Caspi; Karen Sugden; Terrie E Moffitt; Alan Taylor; Ian W Craig; HonaLee Harrington; Joseph McClay; Jonathan Mill; Judy Martin; Antony Braithwaite; Richie Poulton
Journal: Science Date: 2003-07-18 Impact factor: 47.728

5. Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.

Authors: Daniela Tropea; Emanuela Giacometti; Nathan R Wilson; Caroline Beard; Cortina McCurry; Dong Dong Fu; Ruth Flannery; Rudolf Jaenisch; Mriganka Sur
Journal: Proc Natl Acad Sci U S A Date: 2009-02-10 Impact factor: 11.205

6. Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia.

Authors: Benedikt Berninger; Marcos R Costa; Ursula Koch; Timm Schroeder; Bernd Sutor; Benedikt Grothe; Magdalena Götz
Journal: J Neurosci Date: 2007-08-08 Impact factor: 6.167

7. Gene targeting in a HUES line of human embryonic stem cells via electroporation.

Authors: Katherine M Ruby; Binhai Zheng
Journal: Stem Cells Date: 2009-07 Impact factor: 6.277

8. Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.

Authors: Achia Urbach; Ori Bar-Nur; George Q Daley; Nissim Benvenisty
Journal: Cell Stem Cell Date: 2010-05-07 Impact factor: 24.633

9. Somatic coding mutations in human induced pluripotent stem cells.

Authors: Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Journal: Nature Date: 2011-03-03 Impact factor: 49.962

10. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Authors: Gabsang Lee; Eirini P Papapetrou; Hyesoo Kim; Stuart M Chambers; Mark J Tomishima; Christopher A Fasano; Yosif M Ganat; Jayanthi Menon; Fumiko Shimizu; Agnes Viale; Viviane Tabar; Michel Sadelain; Lorenz Studer
Journal: Nature Date: 2009-08-19 Impact factor: 49.962

90 in total

Review 1. Programming and reprogramming neuronal subtypes in the central nervous system.

Authors: Caroline Rouaux; Salman Bhai; Paola Arlotta
Journal: Dev Neurobiol Date: 2012-07 Impact factor: 3.964

Review 2. iPSC-based drug screening for Huntington's disease.

Authors: Ningzhe Zhang; Barbara J Bailus; Karen L Ring; Lisa M Ellerby
Journal: Brain Res Date: 2015-09-30 Impact factor: 3.252

3. Generation of functional human serotonergic neurons from fibroblasts.

Authors: K C Vadodaria; J Mertens; A Paquola; C Bardy; X Li; R Jappelli; L Fung; M C Marchetto; M Hamm; M Gorris; P Koch; F H Gage
Journal: Mol Psychiatry Date: 2015-10-27 Impact factor: 15.992

Review 4. Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons.

Authors: Aaron B Bradford; Patrick M McNutt
Journal: World J Stem Cells Date: 2015-07-26 Impact factor: 5.326

5. Epigenetic therapy for Friedreich ataxia.

Authors: Elisabetta Soragni; Wenyan Miao; Marco Iudicello; David Jacoby; Stefania De Mercanti; Marinella Clerico; Filomena Longo; Antonio Piga; Sherman Ku; Erica Campau; Jintang Du; Pablo Penalver; Myriam Rai; Joseph C Madara; Kristopher Nazor; Melinda O'Connor; Anton Maximov; Jeanne F Loring; Massimo Pandolfo; Luca Durelli; Joel M Gottesfeld; James R Rusche
Journal: Ann Neurol Date: 2014-09-16 Impact factor: 10.422

Review 6. Stem cells and modeling of autism spectrum disorders.

Authors: Beatriz C G Freitas; Cleber A Trujillo; Cassiano Carromeu; Marianna Yusupova; Roberto H Herai; Alysson R Muotri
Journal: Exp Neurol Date: 2012-10-02 Impact factor: 5.330

7. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation.

Authors: Soham Chanda; Samuele Marro; Marius Wernig; Thomas C Südhof
Journal: Proc Natl Acad Sci U S A Date: 2013-09-17 Impact factor: 11.205

8. Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.

Authors: C Bardy; M van den Hurk; B Kakaradov; J A Erwin; B N Jaeger; R V Hernandez; T Eames; A A Paucar; M Gorris; C Marchand; R Jappelli; J Barron; A K Bryant; M Kellogg; R S Lasken; B P F Rutten; H W M Steinbusch; G W Yeo; F H Gage
Journal: Mol Psychiatry Date: 2016-10-04 Impact factor: 15.992

Review 9. Glycosylation and stem cells: Regulatory roles and application of iPSCs in the study of glycosylation-related disorders.

Authors: Ryan P Berger; Michelle Dookwah; Richard Steet; Stephen Dalton
Journal: Bioessays Date: 2016-09-26 Impact factor: 4.345

10. GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.

Authors: Li Li; E Tian; Xianwei Chen; Jianfei Chao; Jeremy Klein; Qiuhao Qu; Guihua Sun; Guoqiang Sun; Yanzhou Huang; Charles D Warden; Peng Ye; Lizhao Feng; Xinqiang Li; Qi Cui; Abdullah Sultan; Panagiotis Douvaras; Valentina Fossati; Neville E Sanjana; Arthur D Riggs; Yanhong Shi
Journal: Cell Stem Cell Date: 2018-08-02 Impact factor: 24.633