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Literature DB >> 23024270

Integrative genomics in cardiovascular medicine.

James S Ware¹, Enrico Petretto, Stuart A Cook.

Abstract

Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and cardiac physiology. Going forward, the integration of comprehensive next-generation sequencing data sets with quantitative phenotypes at the molecular, cellular, and whole-heart level using advanced modelling approaches provides an unprecedented opportunity for cardiovascular science.

Entities: Chemical

Mesh：

Year: 2012 PMID： 23024270 PMCID： PMC3583255 DOI： 10.1093/cvr/cvs303

Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787

56 in total

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Review 6. Genetic Models in Applied Physiology. HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics.

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7. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.

Authors: Chris McDermott-Roe; Junmei Ye; Rizwan Ahmed; Xi-Ming Sun; Anna Serafín; James Ware; Leonardo Bottolo; Phil Muckett; Xavier Cañas; Jisheng Zhang; Glenn C Rowe; Rachel Buchan; Han Lu; Adam Braithwaite; Massimiliano Mancini; David Hauton; Ramon Martí; Elena García-Arumí; Norbert Hubner; Howard Jacob; Tadao Serikawa; Vaclav Zidek; Frantisek Papousek; Frantisek Kolar; Maria Cardona; Marisol Ruiz-Meana; David García-Dorado; Joan X Comella; Leanne E Felkin; Paul J R Barton; Zoltan Arany; Michal Pravenec; Enrico Petretto; Daniel Sanchis; Stuart A Cook
Journal: Nature Date: 2011-10-05 Impact factor: 49.962

8. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.

Authors: Dena G Hernandez; Mike A Nalls; Matthew Moore; Sean Chong; Allissa Dillman; Daniah Trabzuni; J Raphael Gibbs; Mina Ryten; Sampath Arepalli; Michael E Weale; Alan B Zonderman; Juan Troncoso; Richard O'Brien; Robert Walker; Colin Smith; Stefania Bandinelli; Bryan J Traynor; John Hardy; Andrew B Singleton; Mark R Cookson
Journal: Neurobiol Dis Date: 2012-03-12 Impact factor: 5.996

9. Heritability and tissue specificity of expression quantitative trait loci.

Authors: Enrico Petretto; Jonathan Mangion; Nicholas J Dickens; Stuart A Cook; Mande K Kumaran; Han Lu; Judith Fischer; Henrike Maatz; Vladimir Kren; Michal Pravenec; Norbert Hubner; Timothy J Aitman
Journal: PLoS Genet Date: 2006-08-28 Impact factor: 5.917

10. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.

Authors: Enrico Petretto; Rizwan Sarwar; Ian Grieve; Han Lu; Mande K Kumaran; Phillip J Muckett; Jonathan Mangion; Blanche Schroen; Matthew Benson; Prakash P Punjabi; Sanjay K Prasad; Dudley J Pennell; Chris Kiesewetter; Elena S Tasheva; Lolita M Corpuz; Megan D Webb; Gary W Conrad; Theodore W Kurtz; Vladimir Kren; Judith Fischer; Norbert Hubner; Yigal M Pinto; Michal Pravenec; Timothy J Aitman; Stuart A Cook
Journal: Nat Genet Date: 2008-05 Impact factor: 38.330

8 in total

1. Whole-Genome Sequencing and Integrative Genomic Analysis Approach on Two 22q11.2 Deletion Syndrome Family Trios for Genotype to Phenotype Correlations.

Authors: Jonathan H Chung; Jinlu Cai; Barrie G Suskin; Zhengdong Zhang; Karlene Coleman; Bernice E Morrow
Journal: Hum Mutat Date: 2015-07-02 Impact factor: 4.878

2. Sparse simultaneous signal detection for identifying genetically controlled disease genes.

Authors: Sihai Dave Zhao; T Tony Cai; Thomas P Cappola; Kenneth B Margulies; Hongzhe Li
Journal: J Am Stat Assoc Date: 2017-01-05 Impact factor: 5.033

Review 3. Genetics of diabetes complications.

Authors: Sami Alkayyali; Valeriya Lyssenko
Journal: Mamm Genome Date: 2014-08-29 Impact factor: 2.957