Literature DB >> 23024027

Heterologous expression and manipulation of three tetracycline biosynthetic pathways.

Peng Wang1, Woncheol Kim, Lauren B Pickens, Xue Gao, Yi Tang.   

Abstract

A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme).
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23024027      PMCID： PMC4070387          DOI： 10.1002/anie.201205426

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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