Literature DB >> 16246559

Synthesis and antibacterial activity of 9-substituted minocycline derivatives.

Phaik-Eng Sum1, Adma T Ross, Peter J Petersen, Raymond T Testa.   

Abstract

A number of 9-acylamino and 9-sulfonylamino derivatives of minocycline have been synthesized for structure-activity relationship studies. These compounds showed activity against both tetracycline-susceptible and tetracycline-resistant strains. Many of the 9-sulfonylamino derivatives exhibited improved antibacterial activity against a number of tetracycline- and minocycline-resistant Gram-positive pathogens.

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Year:  2005        PMID： 16246559     DOI： 10.1016/j.bmcl.2005.09.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Heterologous expression and manipulation of three tetracycline biosynthetic pathways.

Authors:  Peng Wang; Woncheol Kim; Lauren B Pickens; Xue Gao; Yi Tang
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-28       Impact factor: 15.336

2.  Synthesis and antibacterial activity of doxycycline neoglycosides.

Authors:  Jianjun Zhang; Larissa V Ponomareva; Karen Marchillo; Maoquan Zhou; David R Andes; Jon S Thorson
Journal:  J Nat Prod       Date:  2013-08-29       Impact factor: 4.050

Review 3.  Decoding and engineering tetracycline biosynthesis.

Authors:  Lauren B Pickens; Yi Tang
Journal:  Metab Eng       Date:  2008-10-22       Impact factor: 9.783

4.  Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.

Authors:  Olayinka O Ajani; Oluwole B Familoni; Feipeng Wu; Johnbull O Echeme; Zheng Sujiang
Journal:  Int J Med Chem       Date:  2012-10-17
  4 in total

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