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Literature DB >> 2302191

Fluoroaluminate mimics agonist application in single rat hepatocytes.

N M Woods¹, C J Dixon, K S Cuthbertson, P H Cobbold.

Abstract

Single rat hepatocytes microinjected with the photoprotein aequorin were stimulated with glycogenolytic agonists or low concentrations of fluoroaluminate. Both protocols resulted in the generation of oscillations in cytosolic free Ca2+ levels from a resting value of approx. 200 nM and peaking at over 600 nM. However, oscillations induced by receptor-dependent agonists were more regular in both frequency and time course than those induced by direct activation of G-proteins. The role of G-proteins in the generation of repetitive free Ca2+ oscillations is discussed.

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Year: 1990 PMID： 2302191 PMCID： PMC1136929 DOI： 10.1042/bj2650613

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

1. Repetitive calcium transients in hormone-stimulated cells.

Authors: P Cobbold; M Daly; J Dixon; N Woods
Journal: Biochem Soc Trans Date: 1989-02 Impact factor: 5.407

2. 5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

Authors: I Litosch; C Wallis; J N Fain
Journal: J Biol Chem Date: 1985-05-10 Impact factor: 5.157

3. Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.

Authors: P F Blackmore; J H Exton
Journal: J Biol Chem Date: 1986-08-25 Impact factor: 5.157

4. Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell.

Authors: A Ashkenazi; E G Peralta; J W Winslow; J Ramachandran; D J Capon
Journal: Cell Date: 1989-02-10 Impact factor: 41.582

5. Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.

Authors: N M Woods; K S Cuthbertson; P H Cobbold
Journal: Cell Calcium Date: 1987-02 Impact factor: 6.817

6. Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase.

Authors: S Cockcroft; B D Gomperts
Journal: Nature Date: 1985 Apr 11-17 Impact factor: 49.962

7. Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.

Authors: J E Merritt; C W Taylor; R P Rubin; J W Putney
Journal: Biochem J Date: 1986-06-01 Impact factor: 3.857

4. Aluminum stimulates the proliferation and differentiation of osteoblasts in vitro by a mechanism that is different from fluoride.

Authors: K H Lau; A Yoo; S P Wang
Journal: Mol Cell Biochem Date: 1991-07-10 Impact factor: 3.396

Review 5. Aluminum interaction with phosphoinositide-associated signal transduction.

Authors: A Haug; B Shi; V Vitorello
Journal: Arch Toxicol Date: 1994 Impact factor: 5.153

6. On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea-pig atrial cells.

Authors: W J Zang; X J Yu; H Honjo; M S Kirby; M R Boyett
Journal: J Physiol Date: 1993-05 Impact factor: 5.182

6 in total

Fluoroaluminate mimics agonist application in single rat hepatocytes.

1. Repetitive calcium transients in hormone-stimulated cells.

2. 5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

3. Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.

4. Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell.

5. Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.

6. Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase.

7. Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.

8. Phorbol-ester-induced alterations of free calcium ion transients in single rat hepatocytes.

9. Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes.

Review 10. Signal transduction by guanine nucleotide binding proteins.

1. Receptor-oriented intercellular calcium waves evoked by vasopressin in rat hepatocytes.

2. Aluminium perturbs oscillatory phosphoinositide-mediated calcium signalling in hormone-stimulated hepatocytes.

3. ATP-operated calcium-permeable channels activated via a guanine nucleotide-dependent mechanism in rat macrophages.

4. Aluminum stimulates the proliferation and differentiation of osteoblasts in vitro by a mechanism that is different from fluoride.

Review 5. Aluminum interaction with phosphoinositide-associated signal transduction.

6. On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea-pig atrial cells.