Literature DB >> 23020433

Note: a 4 ns hardware photon correlator based on a general-purpose field-programmable gate array development board implemented in a compact setup for fluorescence correlation spectroscopy.

Stanislav Kalinin1, Ralf Kühnemuth, Hayk Vardanyan, Claus A M Seidel.   

Abstract

We present a fast hardware photon correlator implemented in a field-programmable gate array (FPGA) combined with a compact confocal fluorescence setup. The correlator has two independent units with a time resolution of 4 ns while utilizing less than 15% of a low-end FPGA. The device directly accepts transistor-transistor logic (TTL) signals from two photon counting detectors and calculates two auto- or cross-correlation curves in real time. Test measurements demonstrate that the performance of our correlator is comparable with the current generation of commercial devices. The sensitivity of the optical setup is identical or even superior to current commercial devices. The FPGA design and the optical setup both allow for a straightforward extension to multi-color applications. This inexpensive and compact solution with a very good performance can serve as a versatile platform for uses in education, applied sciences, and basic research.

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Year:  2012        PMID: 23020433     DOI: 10.1063/1.4753994

Source DB:  PubMed          Journal:  Rev Sci Instrum        ISSN: 0034-6748            Impact factor:   1.523


  3 in total

1.  A 32-channel photon counting module with embedded auto/cross-correlators for real-time parallel fluorescence correlation spectroscopy.

Authors:  S Gong; I Labanca; I Rech; M Ghioni
Journal:  Rev Sci Instrum       Date:  2014-10       Impact factor: 1.523

2.  Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable Gate Array.

Authors:  Wei Lin; David R Busch; Chia Chieh Goh; James Barsi; Thomas F Floyd
Journal:  IEEE Access       Date:  2019-08-28       Impact factor: 3.367

3.  Reporting on the future of integrative structural biology ORAU workshop.

Authors:  George L Hamilton; Joshua Alper; Hugo Sanabria
Journal:  Front Biosci (Landmark Ed)       Date:  2020-01-01
  3 in total

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