BACKGROUND: There is a lack of information on stiffness parameter β, an index of arterial stiffness, in hemodialysis (HD) patients. The aim of the present study was to investigate whether stiffness parameter β is predictive of the long-term mortality of chronic HD patients. METHODS: We measured biochemical parameters and the stiffness parameter β of 80 patients on maintenance HD therapy and followed their course for 4 years, and we enrolled 70 of these 80 patients in the study. We divided the 70 patients into tertiles according to their stiffness parameter β values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality. RESULTS: Older age and the presence of diabetes mellitus were found to be independently associated with higher stiffness parameter β values. Fifteen patients (21.4 %) died and 16 (22.9 %) experienced a new cardiovascular event during the follow-up period. The results of a Kaplan-Meier analysis revealed a significantly higher risk of all-cause mortality in the HD patients with highest stiffness parameter β values (p = 0.0106). According to the ROC curve, the cut-off level that yielded maximal sensitivity and specificity for predicting all-cause mortality was 10.1, and the sensitivity and specificity using the cut-off value were 69.2 and 70.2 %, respectively. CONCLUSION: The results of this study suggest that stiffness parameter β is a predictor of all-cause mortality in chronic HD patients.
BACKGROUND: There is a lack of information on stiffness parameter β, an index of arterial stiffness, in hemodialysis (HD) patients. The aim of the present study was to investigate whether stiffness parameter β is predictive of the long-term mortality of chronic HDpatients. METHODS: We measured biochemical parameters and the stiffness parameter β of 80 patients on maintenance HD therapy and followed their course for 4 years, and we enrolled 70 of these 80 patients in the study. We divided the 70 patients into tertiles according to their stiffness parameter β values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality. RESULTS: Older age and the presence of diabetes mellitus were found to be independently associated with higher stiffness parameter β values. Fifteen patients (21.4 %) died and 16 (22.9 %) experienced a new cardiovascular event during the follow-up period. The results of a Kaplan-Meier analysis revealed a significantly higher risk of all-cause mortality in the HDpatients with highest stiffness parameter β values (p = 0.0106). According to the ROC curve, the cut-off level that yielded maximal sensitivity and specificity for predicting all-cause mortality was 10.1, and the sensitivity and specificity using the cut-off value were 69.2 and 70.2 %, respectively. CONCLUSION: The results of this study suggest that stiffness parameter β is a predictor of all-cause mortality in chronic HDpatients.
Authors: Anthony M Dart; Christoph D Gatzka; Bronwyn A Kingwell; Kristyn Willson; James D Cameron; Yu-Lu Liang; Karen L Berry; Lindon M H Wing; Christopher M Reid; Philip Ryan; Lawrence J Beilin; Garry L R Jennings; Colin I Johnston; John J McNeil; Graham J Macdonald; Trefor O Morgan; Malcolm J West Journal: Hypertension Date: 2006-02-27 Impact factor: 10.190
Authors: Jin Hee Jeong; Annabel Biruete; Emily J Tomayko; Pei Tzu Wu; Peter Fitschen; Hae Ryong Chung; Mohamad Ali; Edward McAuley; Bo Fernhall; Shane A Phillips; Kenneth R Wilund Journal: Kidney Int Date: 2019-04-02 Impact factor: 10.612