Literature DB >> 23008217

Sulfonyl fluoride analogues as activity-based probes for serine proteases.

D Alexander Shannon1, Christian Gu, Christopher J McLaughlin, Markus Kaiser, Renier A L van der Hoorn, Eranthie Weerapana.   

Abstract

Enriched with fluoride: To expand on the available tools to interrogate proteases, we explored sulfonyl fluorides as activity-based probes. An alkyne-tagged sulfonyl fluoride covalently modifies members of the S1 family of serine proteases. By applying click chemistry, avidin enrichment and mass spectrometry, we can enrich and identify active endogenous serine proteases from a complex proteome.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23008217     DOI： 10.1002/cbic.201200531

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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