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Literature DB >> 27113843

A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1).

Abstract

Glutathione S-transferase Pi (GSTP1) mediates cellular defense against reactive electrophiles. Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes. Mass spectrometry and mutational studies identified Y108 as the site of modification, providing a unique mode of GSTP1 inhibition.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2016 PMID： 27113843 PMCID： PMC4879005 DOI： 10.1039/c6mb00250a

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

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