Literature DB >> 23006761

Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans.

Nicole Scherr1, Katharina Röltgen, Matthias Witschel, Gerd Pluschke.   

Abstract

An alamarBlue-based growth inhibition assay has been adapted for the thermosensitive and slow-growing pathogen Mycobacterium ulcerans. The standardized test procedure enables medium-throughput screening of preselected compound libraries. Testing of a set of 48 azoles with known antifungal activity led to the identification of an imidazole antifungal displaying an inhibitory dose (ID) of 9 μM for M. ulcerans.

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Year:  2012        PMID： 23006761      PMCID： PMC3497166          DOI： 10.1128/AAC.01383-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals.

Authors:  H Ji; W Zhang; Y Zhou; M Zhang; J Zhu; Y Song; J Lü
Journal:  J Med Chem       Date:  2000-06-29       Impact factor: 7.446

2.  Oral treatment for Mycobacterium ulcerans infection: results from a pilot study in Benin.

Authors:  Annick Chauty; Marie-Françoise Ardant; Laurent Marsollier; Gerd Pluschke; Jordi Landier; Ambroise Adeye; Aimé Goundoté; Jane Cottin; Titilola Ladikpo; Therese Ruf; Baohong Ji
Journal:  Clin Infect Dis       Date:  2011-01-01       Impact factor: 9.079

3.  Comparison of alamar blue and MTT assays for high through-put screening.

Authors:  R Hamid; Y Rotshteyn; L Rabadi; R Parikh; P Bullock
Journal:  Toxicol In Vitro       Date:  2004-10       Impact factor: 3.500

4.  Pilot randomized double-blind trial of treatment of Mycobacterium ulcerans disease (Buruli ulcer) with topical nitrogen oxides.

Authors:  R Phillips; O Adjei; S Lucas; N Benjamin; M Wansbrough-Jones
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

5.  New anti-tuberculosis agents amongst known drugs.

Authors:  Kathryn E A Lougheed; Debra L Taylor; Simon A Osborne; Justin S Bryans; Roger S Buxton
Journal:  Tuberculosis (Edinb)       Date:  2009-08-20       Impact factor: 3.131

6.  Synthesis and antifungal activity of new 1-vinylimidazoles.

Authors:  M Ogata; H Matsumoto; S Shimizu; S Kida; M Shiro; K Tawara
Journal:  J Med Chem       Date:  1987-08       Impact factor: 7.446

7.  Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.

Authors:  Kirsty J McLean; Ker R Marshall; Alison Richmond; Iain S Hunter; Kay Fowler; Tobias Kieser; Sudagar S Gurcha; Gurydal S Besra; Andrew W Munro
Journal:  Microbiology       Date:  2002-10       Impact factor: 2.777

8.  Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice.

Authors:  Laurent Marsollier; Nadine Honoré; Pierre Legras; Anne Lise Manceau; Henri Kouakou; Bernard Carbonnelle; Stewart T Cole
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

9.  Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice.

Authors:  Deepak Almeida; Paul J Converse; Zahoor Ahmad; Kelly E Dooley; Eric L Nuermberger; Jacques H Grosset
Journal:  PLoS Negl Trop Dis       Date:  2011-01-04

10.  Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing.

Authors:  Weihong Qi; Michael Käser; Katharina Röltgen; Dorothy Yeboah-Manu; Gerd Pluschke
Journal:  PLoS Pathog       Date:  2009-09-11       Impact factor: 6.823
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  4 in total

1.  Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans.

Authors:  Nicole Scherr; Gerd Pluschke; Manoranjan Panda
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

2.  The Frequency, Antifungal Susceptibility and Enzymatic Profiles of Candida Species Isolated from Neutropenic Patients.

Authors:  Maral Gharaghani; Ali Rezaei-Matehkolaei; Ali Zarei Mahmoudabadi; Bijan Keikhaei
Journal:  Jundishapur J Microbiol       Date:  2016-10-09       Impact factor: 0.747

Review 3.  Update on Medicinal Plants with Potency on Mycobacterium ulcerans.

Authors:  Patrick Valere Tsouh Fokou; Alexander Kwadwo Nyarko; Regina Appiah-Opong; Lauve Rachel Tchokouaha Yamthe; Mark Ofosuhene; Fabrice Fekam Boyom
Journal:  Biomed Res Int       Date:  2015-12-08       Impact factor: 3.411

4.  Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening.

Authors:  María Pilar Arenaz-Callao; Rubén González Del Río; Ainhoa Lucía Quintana; Charles J Thompson; Alfonso Mendoza-Losana; Santiago Ramón-García
Journal:  PLoS Negl Trop Dis       Date:  2019-01-28
  4 in total

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