Literature DB >> 3302257

Synthesis and antifungal activity of new 1-vinylimidazoles.

M Ogata, H Matsumoto, S Shimizu, S Kida, M Shiro, K Tawara.   

Abstract

Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

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Year:  1987        PMID: 3302257     DOI: 10.1021/jm00391a014

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  3 in total

1.  Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans.

Authors:  Nicole Scherr; Katharina Röltgen; Matthias Witschel; Gerd Pluschke
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

2.  Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.

Authors:  Matthias Witschel; Matthias Rottmann; Marcel Kaiser; Reto Brun
Journal:  PLoS Negl Trop Dis       Date:  2012-10-25

Review 3.  Conazoles.

Authors:  Jan Heeres; Lieven Meerpoel; Paul Lewi
Journal:  Molecules       Date:  2010-06-09       Impact factor: 4.411

  3 in total

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