Literature DB >> 22999960

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.

Luis G Carvajal-Carmona1, Ann G Zauber, Angela M Jones, Kimberley Howarth, Jiping Wang, Timothy Cheng, Robert Riddell, Angel Lanas, Dion Morton, Monica M Bertagnolli, Ian Tomlinson.   

Abstract

Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22999960      PMCID： PMC3572711          DOI： 10.1053/j.gastro.2012.09.016

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  15 in total

1.  Celecoxib for the prevention of sporadic colorectal adenomas.

Authors:  Monica M Bertagnolli; Craig J Eagle; Ann G Zauber; Mark Redston; Scott D Solomon; KyungMann Kim; Jie Tang; Rebecca B Rosenstein; Janet Wittes; Donald Corle; Timothy M Hess; G Mabel Woloj; Frédéric Boisserie; William F Anderson; Jaye L Viner; Donya Bagheri; John Burn; Daniel C Chung; Thomas Dewar; T Raymond Foley; Neville Hoffman; Finlay Macrae; Ronald E Pruitt; John R Saltzman; Bruce Salzberg; Thomas Sylwestrowicz; Gary B Gordon; Ernest T Hawk
Journal:  N Engl J Med       Date:  2006-08-31       Impact factor: 91.245

2.  A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.

Authors:  David J Hunter; Peter Kraft; Kevin B Jacobs; David G Cox; Meredith Yeager; Susan E Hankinson; Sholom Wacholder; Zhaoming Wang; Robert Welch; Amy Hutchinson; Junwen Wang; Kai Yu; Nilanjan Chatterjee; Nick Orr; Walter C Willett; Graham A Colditz; Regina G Ziegler; Christine D Berg; Saundra S Buys; Catherine A McCarty; Heather Spencer Feigelson; Eugenia E Calle; Michael J Thun; Richard B Hayes; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert N Hoover; Gilles Thomas; Stephen J Chanock
Journal:  Nat Genet       Date:  2007-05-27       Impact factor: 38.330

3.  A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Authors:  Ian P M Tomlinson; Emily Webb; Luis Carvajal-Carmona; Peter Broderick; Kimberley Howarth; Alan M Pittman; Sarah Spain; Steven Lubbe; Axel Walther; Kate Sullivan; Emma Jaeger; Sarah Fielding; Andrew Rowan; Jayaram Vijayakrishnan; Enric Domingo; Ian Chandler; Zoe Kemp; Mobshra Qureshi; Susan M Farrington; Albert Tenesa; James G D Prendergast; Rebecca A Barnetson; Steven Penegar; Ella Barclay; Wendy Wood; Lynn Martin; Maggie Gorman; Huw Thomas; Julian Peto; D Timothy Bishop; Richard Gray; Eamonn R Maher; Anneke Lucassen; David Kerr; D Gareth R Evans; Clemens Schafmayer; Stephan Buch; Henry Völzke; Jochen Hampe; Stefan Schreiber; Ulrich John; Thibaud Koessler; Paul Pharoah; Tom van Wezel; Hans Morreau; Juul T Wijnen; John L Hopper; Melissa C Southey; Graham G Giles; Gianluca Severi; Sergi Castellví-Bel; Clara Ruiz-Ponte; Angel Carracedo; Antoni Castells; Asta Försti; Kari Hemminki; Pavel Vodicka; Alessio Naccarati; Lara Lipton; Judy W C Ho; K K Cheng; Pak C Sham; J Luk; Jose A G Agúndez; Jose M Ladero; Miguel de la Hoya; Trinidad Caldés; Iina Niittymäki; Sari Tuupanen; Auli Karhu; Lauri Aaltonen; Jean-Baptiste Cazier; Harry Campbell; Malcolm G Dunlop; Richard S Houlston
Journal:  Nat Genet       Date:  2008-03-30       Impact factor: 38.330

4.  Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer.

Authors:  Polly A Newcomb; John Baron; Michelle Cotterchio; Steve Gallinger; John Grove; Robert Haile; David Hall; John L Hopper; Jeremy Jass; Loïc Le Marchand; Paul Limburg; Noralane Lindor; John D Potter; Allyson S Templeton; Steve Thibodeau; Daniela Seminara
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2007-11-02       Impact factor: 4.254

5.  Natural history of untreated colonic polyps.

Authors:  S J Stryker; B G Wolff; C E Culp; S D Libbe; D M Ilstrup; R L MacCarty
Journal:  Gastroenterology       Date:  1987-11       Impact factor: 22.682

6.  Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

Authors:  Richard S Houlston; Emily Webb; Peter Broderick; Alan M Pittman; Maria Chiara Di Bernardo; Steven Lubbe; Ian Chandler; Jayaram Vijayakrishnan; Kate Sullivan; Steven Penegar; Luis Carvajal-Carmona; Kimberley Howarth; Emma Jaeger; Sarah L Spain; Axel Walther; Ella Barclay; Lynn Martin; Maggie Gorman; Enric Domingo; Ana S Teixeira; David Kerr; Jean-Baptiste Cazier; Iina Niittymäki; Sari Tuupanen; Auli Karhu; Lauri A Aaltonen; Ian P M Tomlinson; Susan M Farrington; Albert Tenesa; James G D Prendergast; Rebecca A Barnetson; Roseanne Cetnarskyj; Mary E Porteous; Paul D P Pharoah; Thibaud Koessler; Jochen Hampe; Stephan Buch; Clemens Schafmayer; Jurgen Tepel; Stefan Schreiber; Henry Völzke; Jenny Chang-Claude; Michael Hoffmeister; Hermann Brenner; Brent W Zanke; Alexandre Montpetit; Thomas J Hudson; Steven Gallinger; Harry Campbell; Malcolm G Dunlop
Journal:  Nat Genet       Date:  2008-11-16       Impact factor: 38.330

7.  Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

Authors:  Emma Jaeger; Emily Webb; Kimberley Howarth; Luis Carvajal-Carmona; Andrew Rowan; Peter Broderick; Axel Walther; Sarah Spain; Alan Pittman; Zoe Kemp; Kate Sullivan; Karl Heinimann; Steven Lubbe; Enric Domingo; Ella Barclay; Lynn Martin; Maggie Gorman; Ian Chandler; Jayaram Vijayakrishnan; Wendy Wood; Elli Papaemmanuil; Steven Penegar; Mobshra Qureshi; Susan Farrington; Albert Tenesa; Jean-Baptiste Cazier; David Kerr; Richard Gray; Julian Peto; Malcolm Dunlop; Harry Campbell; Huw Thomas; Richard Houlston; Ian Tomlinson
Journal:  Nat Genet       Date:  2007-12-16       Impact factor: 38.330

8.  A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.

Authors:  Ian Tomlinson; Emily Webb; Luis Carvajal-Carmona; Peter Broderick; Zoe Kemp; Sarah Spain; Steven Penegar; Ian Chandler; Maggie Gorman; Wendy Wood; Ella Barclay; Steven Lubbe; Lynn Martin; Gabrielle Sellick; Emma Jaeger; Richard Hubner; Ruth Wild; Andrew Rowan; Sarah Fielding; Kimberley Howarth; Andrew Silver; Wendy Atkin; Kenneth Muir; Richard Logan; David Kerr; Elaine Johnstone; Oliver Sieber; Richard Gray; Huw Thomas; Julian Peto; Jean-Baptiste Cazier; Richard Houlston
Journal:  Nat Genet       Date:  2007-07-08       Impact factor: 38.330

9.  Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

Authors:  Richard S Houlston; Jeremy Cheadle; Sara E Dobbins; Albert Tenesa; Angela M Jones; Kimberley Howarth; Sarah L Spain; Peter Broderick; Enric Domingo; Susan Farrington; James G D Prendergast; Alan M Pittman; Evi Theodoratou; Christopher G Smith; Bianca Olver; Axel Walther; Rebecca A Barnetson; Michael Churchman; Emma E M Jaeger; Steven Penegar; Ella Barclay; Lynn Martin; Maggie Gorman; Rachel Mager; Elaine Johnstone; Rachel Midgley; Iina Niittymäki; Sari Tuupanen; James Colley; Shelley Idziaszczyk; Huw J W Thomas; Anneke M Lucassen; D Gareth R Evans; Eamonn R Maher; Timothy Maughan; Antigone Dimas; Emmanouil Dermitzakis; Jean-Baptiste Cazier; Lauri A Aaltonen; Paul Pharoah; David J Kerr; Luis G Carvajal-Carmona; Harry Campbell; Malcolm G Dunlop; Ian P M Tomlinson
Journal:  Nat Genet       Date:  2010-10-24       Impact factor: 38.330

10.  Association of colorectal adenoma with other malignancies in Swedish families.

Authors:  E Hiripi; J Lorenzo Bermejo; J Sundquist; K Hemminki
Journal:  Br J Cancer       Date:  2008-02-19       Impact factor: 7.640
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  26 in total

1.  The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

Authors:  Ruta Sahasrabudhe; Ana Estrada; Paul Lott; Lynn Martin; Guadalupe Polanco Echeverry; Alejandro Velez; Gila Neta; Meiko Takahasi; Vladimir Saenko; Norisato Mitsutake; Emma Jaeguer; Carlos Simon Duque; Alejandro Rios; Mabel Bohorquez; Rodrigo Prieto; Angel Criollo; Magdalena Echeverry; Ian Tomlinson; Luis G Carvajal Carmona
Journal:  Endocr Relat Cancer       Date:  2015-08-19       Impact factor: 5.678

2.  Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.

Authors:  Adria Closa; David Cordero; Rebeca Sanz-Pamplona; Xavier Solé; Marta Crous-Bou; Laia Paré-Brunet; Antoni Berenguer; Elisabet Guino; Adriana Lopez-Doriga; Jordi Guardiola; Sebastiano Biondo; Ramon Salazar; Victor Moreno
Journal:  Carcinogenesis       Date:  2014-04-23       Impact factor: 4.944

3.  Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.

Authors:  Ting-Ting Geng; Xiao-Jie Xun; Sen Li; Tian Feng; Li-Ping Wang; Tian-Bo Jin; Peng Hou
Journal:  World J Gastroenterol       Date:  2015-06-14       Impact factor: 5.742

4.  Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population.

Authors:  Korbinian Weigl; Hauke Thomsen; Yesilda Balavarca; Jacklyn N Hellwege; Martha J Shrubsole; Hermann Brenner
Journal:  Gastroenterology       Date:  2018-03-21       Impact factor: 22.682

5.  Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility.

Authors:  Ming Li; Yahong Gu
Journal:  Mol Genet Genomics       Date:  2014-10-08       Impact factor: 3.291

6.  Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies.

Authors:  Lin Tu; Bin Yan; Zhiyong Peng
Journal:  Mol Genet Genomics       Date:  2014-12-05       Impact factor: 3.291

7.  Evaluation of genetic variants in association with colorectal cancer risk and survival in Asians.

Authors:  Nan Wang; Yingchang Lu; Nikhil K Khankari; Jirong Long; Hong-Lan Li; Jing Gao; Yu-Tang Gao; Yong-Bing Xiang; Xiao-Ou Shu; Wei Zheng
Journal:  Int J Cancer       Date:  2017-06-21       Impact factor: 7.396

8.  Variation in the association between colorectal cancer susceptibility loci and colorectal polyps by polyp type.

Authors:  Andrea N Burnett-Hartman; Polly A Newcomb; Carolyn M Hutter; Ulrike Peters; Michael N Passarelli; Malaika R Schwartz; Melissa P Upton; Lee-Ching Zhu; John D Potter; Karen W Makar
Journal:  Am J Epidemiol       Date:  2014-05-29       Impact factor: 4.897

Review 9.  Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.

Authors:  Zahra Montazeri; Evropi Theodoratou; Christine Nyiraneza; Maria Timofeeva; Wanjing Chen; Victoria Svinti; Shanya Sivakumaran; Gillian Gresham; Laura Cubitt; Luis Carvajal-Carmona; Monica M Bertagnolli; Ann G Zauber; Ian Tomlinson; Susan M Farrington; Malcolm G Dunlop; Harry Campbell; Julian Little
Journal:  Int J Epidemiol       Date:  2015-10-07       Impact factor: 7.196

10.  Common variation rs6983267 at 8q24.1 and risk of colorectal adenoma and cancer: evidence based on 31 studies.

Authors:  Yin-Ping Wang; Jie Zhang; Hong-Yi Zhu; Chang-Ling Qian; Hua Liu; Fu Ji; Zhi-Yong Shen
Journal:  Tumour Biol       Date:  2013-12-28
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