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Literature DB >> 2298456

Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer.

E van den Berg-de Ruiter¹, B de Jong, N H Mulder, G J te Meerman, H Schraffordt Koops, D T Sleijfer.

Abstract

We describe the presence of a large number of chromosome aberrations in lymphocytes of 50 patients with testicular cancer. These chromosomal aberrations were not only found in patients treated with chemotherapy but also in untreated patients or in patients after surgery alone. Our results suggest a role for genetic instability in the pathogenesis of testicular cancer. This instability might be a risk factor for the development of secondary malignancies.

Entities: Disease Species

Mesh：

Year: 1990 PMID： 2298456 DOI： 10.1007/bf00208940

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

28 in total

1. Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability.

Authors: L Barrios; M R Caballín; R Mirò; C Fuster; G Berrozpe; A Subías; X Batlle; J Egozcue
Journal: Hum Genet Date: 1988-04 Impact factor: 4.132

2. Deficiency of all or part of chromosome 11 in several types of cancer: significance of a reduction in the number of normal chromosomes 11.

Authors: N B Atkin; M C Baker
Journal: Cytogenet Cell Genet Date: 1988

3. Treatment of retroperitoneal residual tumor after PVB chemotherapy of nonseminomatous testicular tumors.

Authors: W A Gelderman; H S Koops; D T Sleijfer; J W Oosterhuis; J Oldhoff
Journal: Cancer Date: 1986-10-01 Impact factor: 6.860

4. The frequency of chromosome aberrations in a control population.

Authors: E J Tawn
Journal: Mutat Res Date: 1987-12 Impact factor: 2.433

5. Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukemia.

Authors: F Mitelman; L Brandt; P G Nilsson
Journal: Blood Date: 1978-12 Impact factor: 22.113

Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer.

1. Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability.

2. Deficiency of all or part of chromosome 11 in several types of cancer: significance of a reduction in the number of normal chromosomes 11.

3. Treatment of retroperitoneal residual tumor after PVB chemotherapy of nonseminomatous testicular tumors.

4. The frequency of chromosome aberrations in a control population.

5. Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukemia.

6. Hereditary cancers disclose a class of cancer genes.

7. Testicular cancer as a model for a curable neoplasm: The Richard and Hinda Rosenthal Foundation Award Lecture.

8. Cytogenetic effect of carboplatin on human lymphocytes.

9. Increased mutation frequency following treatment with cancer chemotherapy.

Review 10. Occupational history and involvement of chromosomes 5 and 7 in acute nonlymphocytic leukemia.

1. No evidence for constitutional chromosome instability in testicular cancer.

2. Chromosomal damage in lymphocytes and fibroblasts of patients treated for testicular cancer.

3. Cytogenetic studies of chromosome aberrations.

4. Cytogenetic studies in lymphocytes of patients with rectal cancer.