BACKGROUND: Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of sodium excretion has been described. The aim of this work was to study the influence of bariatric surgery on sodium excretion at more than a year after the intervention. METHODS: Patients who have undergone Roux-en-Y gastric bypass (RYGB) and who had collected a 24-h urine sample before surgery more than 12 months ago were asked to participate. A second 24-h urine sample was collected. Blood pressure and weight were measured. The difference in sodium excretion before and after surgery was calculated, and the relationship with blood pressure and weight loss was investigated. RESULTS: We included 33 patients; the median follow-up time was 21 months (range 14-41). Sodium excretion was high before surgery (median 195 mmol/day, IQR range 167-247) and decreased by 18 % after surgery (median 160 mmol/day, IQR range 118-205, p = 0.015), while there were significant improvements in body weight (% EWL 80.9 ± 21.8), systolic blood pressure (126 to 120 mmHg, p = 0.02), and diastolic blood pressure (84 to 77 mmHg, p = 0.002), even with a reduced number of antihypertensive drugs. CONCLUSIONS: After RYGB and considerable weight loss, sodium excretion remains high in the longer term. The profound improvement in blood pressure cannot be explained by reductions in sodium excretion after RYGB.
BACKGROUND: Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of sodium excretion has been described. The aim of this work was to study the influence of bariatric surgery on sodium excretion at more than a year after the intervention. METHODS:Patients who have undergone Roux-en-Y gastric bypass (RYGB) and who had collected a 24-h urine sample before surgery more than 12 months ago were asked to participate. A second 24-h urine sample was collected. Blood pressure and weight were measured. The difference in sodium excretion before and after surgery was calculated, and the relationship with blood pressure and weight loss was investigated. RESULTS: We included 33 patients; the median follow-up time was 21 months (range 14-41). Sodium excretion was high before surgery (median 195 mmol/day, IQR range 167-247) and decreased by 18 % after surgery (median 160 mmol/day, IQR range 118-205, p = 0.015), while there were significant improvements in body weight (% EWL 80.9 ± 21.8), systolic blood pressure (126 to 120 mmHg, p = 0.02), and diastolic blood pressure (84 to 77 mmHg, p = 0.002), even with a reduced number of antihypertensive drugs. CONCLUSIONS: After RYGB and considerable weight loss, sodium excretion remains high in the longer term. The profound improvement in blood pressure cannot be explained by reductions in sodium excretion after RYGB.
Authors: Varun Agrawal; Kevin R Krause; David L Chengelis; Kerstyn C Zalesin; Leslie L Rocher; Peter A McCullough Journal: Surg Obes Relat Dis Date: 2008-08-05 Impact factor: 4.734
Authors: T Konta; Z Hao; H Abiko; M Ishikawa; T Takahashi; A Ikeda; K Ichikawa; S Takasaki; I Kubota Journal: Kidney Int Date: 2006-08 Impact factor: 10.612
Authors: Luigi X Cubeddu; Irene S Hoffmann; Lisette M Aponte; Rosaura Nuñez-Bogesits; Helimenia Medina-Suniaga; Magaly Roa; Robert S Garcia Journal: Am J Hypertens Date: 2003-05 Impact factor: 2.689
Authors: Jing Chen; Dongfeng Gu; Jianfeng Huang; Dabeeru C Rao; Cashell E Jaquish; James E Hixson; Chung-Shiuan Chen; Jichun Chen; Fanghong Lu; Dongsheng Hu; Treva Rice; Tanika N Kelly; L Lee Hamm; Paul K Whelton; Jiang He Journal: Lancet Date: 2009-02-14 Impact factor: 79.321