Hongyan Huang1,2,3, Jun Lu4, Xiaojiang Dai1,2, Zhixin Li5, Liyong Zhu6, Shaihong Zhu6, Liangping Wu7,8. 1. Surgical Center for Obesity and Diabetes, Jinshazhou Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510515, China. 2. UDM Medical Group, Guangzhou, 510515, China. 3. Clinical Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. 4. School of Medicine, Hunan Normal University, Changsha, 410013, China. 5. Clinical Medicine Eight-Year Program, Xiangya School of Medicine, Central South University, 18 Grade, Changsha, 410013, China. 6. Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, 410013, China. 7. Surgical Center for Obesity and Diabetes, Jinshazhou Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510515, China. drwulp@163.com. 8. UDM Medical Group, Guangzhou, 510515, China. drwulp@163.com.
Abstract
BACKGROUND/ OBJECTIVE: The effect of bariatric surgery in renal function varies and the postoperative benefit time point remains unclear. We aim to assess the changes of renal function after bariatric surgery (BS) in different postoperative periods and subgroups. METHODS: We searched the databases of PubMed and Cochrane from inception to December 14, 2020. Articles included in the study were drawn from all recipients of BS that provided assessments of renal function pre and post-surgery. Meta-analysis was performed to compare glomerular filtration rate (GFR), serum creatinine, albumin-to-creatinine ratio (ACR), and albuminuria before and after BS. RESULTS: The study included 49 articles involving 8515 patients. Compared with pre-operative renal function, the overall analysis showed that bariatric surgery significantly reduced serum creatinine levels, ACR, and albuminuria. There was significant increase of GFR in the CKD subgroup, yet a noticeable decrease in the hyperfiltration subgroup. The most significant improvement in GFR was seen 6-12 months after BS, while ACR dropped most dramatically 12-24 months after BS. CONCLUSIONS: Bariatric surgery can improve renal function in obese patients with kidney dysfunction, especially 1 year after surgery.
BACKGROUND/ OBJECTIVE: The effect of bariatric surgery in renal function varies and the postoperative benefit time point remains unclear. We aim to assess the changes of renal function after bariatric surgery (BS) in different postoperative periods and subgroups. METHODS: We searched the databases of PubMed and Cochrane from inception to December 14, 2020. Articles included in the study were drawn from all recipients of BS that provided assessments of renal function pre and post-surgery. Meta-analysis was performed to compare glomerular filtration rate (GFR), serum creatinine, albumin-to-creatinine ratio (ACR), and albuminuria before and after BS. RESULTS: The study included 49 articles involving 8515 patients. Compared with pre-operative renal function, the overall analysis showed that bariatric surgery significantly reduced serum creatinine levels, ACR, and albuminuria. There was significant increase of GFR in the CKD subgroup, yet a noticeable decrease in the hyperfiltration subgroup. The most significant improvement in GFR was seen 6-12 months after BS, while ACR dropped most dramatically 12-24 months after BS. CONCLUSIONS: Bariatric surgery can improve renal function in obesepatients with kidney dysfunction, especially 1 year after surgery.
Authors: Antonio Carbone; Yazan Al Salhi; Andrea Tasca; Giovanni Palleschi; Andrea Fuschi; Cosimo De Nunzio; Giorgio Bozzini; Sandro Mazzaferro; Antonio L Pastore Journal: Minerva Urol Nefrol Date: 2018-05-31 Impact factor: 3.720
Authors: Elisenda Climent; David Benaiges; Juan Pedro-Botet; Juana A Flores-Le Roux; Jose M Ramón; Montserrat Villatoro; Laia Fontané; Juan J Chillarón; Albert Goday Journal: Obes Surg Date: 2017-06 Impact factor: 4.129
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