Josue Emiliano López-Martínez1, Adolfo Chávez-Negrete2, Arturo Abraham Rodríguez-González3, Mario Antonio Molina-Ayala4, Silvia Villanueva-Recillas5, Pablo Maravilla6, Aida Monserrat Reséndiz-Barragán7, Enrique Rentería-Palomo8, Martín Edgardo Rojano-Rodríguez9. 1. Department of Continuous Admission Service, Hospital of Specialties at La Raza National Medical Center, IMSS, Seris y Zaachila Col La Raza Del Azcapotzalco, 23065, Mexico City, Mexico. 2. Director of Education and Research in Health, Hospital of Specialties at XXI Century National Medical Center, IMSS, Cuauhtémoc 330, Colonia Doctores, 02070, Mexico City, Mexico. 3. Department of General and Bariatric Surgery, Hospital of Specialties at XXI Century National Medical Center, IMSS, Cuauhtémoc 330, Colonia Doctores, 02070, Mexico City, Mexico. 4. Department of Endocrinology and Obesity Clinic, Hospital of Specialties at XXI Century National Medical Center, IMSS, Cuauhtémoc 330, Colonia Doctores, 02070, Mexico City, Mexico. 5. Central Chemistry Laboratories, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico. 6. Department of Clinical Investigation, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico. 7. Obesity and Metabolic Clinic, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico. 8. Department of General and Endoscopic Surgery, General Hospital Dr. Manuel Gea González, Calzada de Tlalpan 4800, 14050, Mexico City, Mexico. 9. Department of Endoscopic, Minimally Invasive Gastrointestinal and Bariatric Surgery, General Hospital Dr. Manuel Gea González, CdMX. Calzada de Tlalpan 4800. Col. Sección XVI, 14050, Mexico City, Mexico. drrojano@icloud.com.
Abstract
INTRODUCTION: Bariatric surgery has been shown to be effective in reducing weight and has benefits, such as lowering blood pressure. An increase in urinary sodium excretion has been suggested as a possible mechanism. This study explored changes in sodium excretion and their correlation with blood pressure after Roux-en-Y gastric bypass. MATERIALS AND METHODS: This study was conducted on 28 obese participants with body mass index (BMI) of 44.54 ± 7.81 kg/m2 who underwent gastric bypass. Before surgery and at the third and sixth months after gastric bypass, blood pressure, urinary sodium concentration, 24-hour (24-h) urinary sodium excretion, and fractional excretion of sodium were evaluated. In addition, serum sodium and potassium levels were determined. Nonparametric tests were used to analyze the data. RESULTS: Blood pressure decreased after surgery and remained at low levels over the 3- and 6-month periods. The urinary sodium concentration increased at 3 months after surgery; however, the 24-h urinary sodium excretion and urine volume decreased. Interestingly, although some associations between variables were observed, significant correlations between the 24-h urinary sodium excretion and the systolic, diastolic, and mean blood pressures were found. In addition, the urine volume was higher in the sixth month than in the third month following surgery. CONCLUSIONS: In the months immediately following surgery, a low-salt and low-volume diet favors decreases in urine volume and 24-h urinary sodium excretion. In addition, in the sixth month after surgery, an association between blood pressure and 24-h urinary sodium excretion was observed.
INTRODUCTION: Bariatric surgery has been shown to be effective in reducing weight and has benefits, such as lowering blood pressure. An increase in urinary sodium excretion has been suggested as a possible mechanism. This study explored changes in sodium excretion and their correlation with blood pressure after Roux-en-Y gastric bypass. MATERIALS AND METHODS: This study was conducted on 28 obeseparticipants with body mass index (BMI) of 44.54 ± 7.81 kg/m2 who underwent gastric bypass. Before surgery and at the third and sixth months after gastric bypass, blood pressure, urinary sodium concentration, 24-hour (24-h) urinary sodium excretion, and fractional excretion of sodium were evaluated. In addition, serum sodium and potassium levels were determined. Nonparametric tests were used to analyze the data. RESULTS: Blood pressure decreased after surgery and remained at low levels over the 3- and 6-month periods. The urinary sodium concentration increased at 3 months after surgery; however, the 24-h urinary sodium excretion and urine volume decreased. Interestingly, although some associations between variables were observed, significant correlations between the 24-h urinary sodium excretion and the systolic, diastolic, and mean blood pressures were found. In addition, the urine volume was higher in the sixth month than in the third month following surgery. CONCLUSIONS: In the months immediately following surgery, a low-salt and low-volume diet favors decreases in urine volume and 24-h urinary sodium excretion. In addition, in the sixth month after surgery, an association between blood pressure and 24-h urinary sodium excretion was observed.
Authors: María Elena Romero-Lbargüengoitia; Israel Lerman-Garber; Miguel Francisco Herrera-Hernández; Juan Pablo-Pantoja; Mauricio Sierra-Salazar; Federico López-Rosales; Margarita Zamora-Barrón; Angeles Vargas-Martínez; Eduardo García-García Journal: Rev Invest Clin Date: 2009 May-Jun Impact factor: 1.451