BACKGROUND AND PURPOSE: MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI. MATERIALS AND METHODS: Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs. RESULTS: The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI. CONCLUSIONS: Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes.
BACKGROUND AND PURPOSE: MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI. MATERIALS AND METHODS: Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs. RESULTS: The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI. CONCLUSIONS: Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes.
Authors: Stephen M Smith; Heidi Johansen-Berg; Mark Jenkinson; Daniel Rueckert; Thomas E Nichols; Karla L Miller; Matthew D Robson; Derek K Jones; Johannes C Klein; Andreas J Bartsch; Timothy E J Behrens Journal: Nat Protoc Date: 2007 Impact factor: 13.491
Authors: Laurence O'Dwyer; Franck Lamberton; Arun L W Bokde; Michael Ewers; Yetunde O Faluyi; Colby Tanner; Bernard Mazoyer; Desmond O'Neill; Máiréad Bartley; D Rónán Collins; Tara Coughlan; David Prvulovic; Harald Hampel Journal: PLoS One Date: 2012-02-23 Impact factor: 3.240
Authors: Stefan Klöppel; Cynthia M Stonnington; Carlton Chu; Bogdan Draganski; Rachael I Scahill; Jonathan D Rohrer; Nick C Fox; Clifford R Jack; John Ashburner; Richard S J Frackowiak Journal: Brain Date: 2008-01-17 Impact factor: 13.501