Literature DB >> 22974177

Organic radical contrast agents for magnetic resonance imaging.

Andrzej Rajca1, Ying Wang, Michael Boska, Joseph T Paletta, Arnon Olankitwanit, Michael A Swanson, Deborah G Mitchell, Sandra S Eaton, Gareth R Eaton, Suchada Rajca.   

Abstract

We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular (1)H water relaxivity (r(1)) is ca. 5 mM(-1) s(-1). The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.

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Year:  2012        PMID： 22974177      PMCID： PMC3486519          DOI： 10.1021/ja3079829

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  26 in total

1.  Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?

Authors:  Thomas Grobner
Journal:  Nephrol Dial Transplant       Date:  2006-01-23       Impact factor: 5.992

2.  Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione.

Authors:  Andrey A Bobko; Igor A Kirilyuk; Igor A Grigor'ev; Jay L Zweier; Valery V Khramtsov
Journal:  Free Radic Biol Med       Date:  2006-11-10       Impact factor: 7.376

3.  A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

Authors:  Ryan M Davis; Anastasia L Sowers; William DeGraff; Marcelino Bernardo; Angela Thetford; Murali C Krishna; James B Mitchell
Journal:  Free Radic Biol Med       Date:  2011-05-25       Impact factor: 7.376

4.  Conjugation effects of various linkers on Gd(III) MRI contrast agents with dendrimers: optimizing the hydroxypyridinonate (HOPO) ligands with nontoxic, degradable esteramide (EA) dendrimers for high relaxivity.

Authors:  William C Floyd; Piper J Klemm; Danil E Smiles; Ayano C Kohlgruber; Valérie C Pierre; Justin L Mynar; Jean M J Fréchet; Kenneth N Raymond
Journal:  J Am Chem Soc       Date:  2011-02-04       Impact factor: 15.419

5.  Impact of electron-electron spin interaction on electron spin relaxation of nitroxide diradicals and tetraradical in glassy solvents between 10 and 300 k.

Authors:  Hideo Sato; Velavan Kathirvelu; Gaëlle Spagnol; Suchada Rajca; Andrzej Rajca; Sandra S Eaton; Gareth R Eaton
Journal:  J Phys Chem B       Date:  2008-02-20       Impact factor: 2.991

6.  Relaxivity enhancement of low molecular weight nitroxide stable free radicals: importance of structure and medium.

Authors:  P Vallet; Y Van Haverbeke; P A Bonnet; G Subra; J P Chapat; R N Muller
Journal:  Magn Reson Med       Date:  1994-07       Impact factor: 4.668

Review 7.  Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier.

Authors:  Börje Haraldsson; Jenny Sörensson
Journal:  News Physiol Sci       Date:  2004-02

8.  Synthesis of 2,5-bis(spirocyclohexane)-substituted nitroxides of pyrroline and pyrrolidine series, including thiol-specific spin label: an analogue of MTSSL with long relaxation time.

Authors:  Igor A Kirilyuk; Yuliya F Polienko; Olesya A Krumkacheva; Rodion K Strizhakov; Yurii V Gatilov; Igor A Grigor'ev; Elena G Bagryanskaya
Journal:  J Org Chem       Date:  2012-09-04       Impact factor: 4.354

9.  Targeted dendrimer-based contrast agents for articular cartilage assessment by MR imaging.

Authors:  C S Winalski; S Shortkroff; E Schneider; H Yoshioka; R V Mulkern; G M Rosen
Journal:  Osteoarthritis Cartilage       Date:  2008-01-15       Impact factor: 6.576

10.  Kinetics of nitroxide spin label removal in biological systems: an in vitro and in vivo ESR study.

Authors:  F Vianello; F Momo; M Scarpa; A Rigo
Journal:  Magn Reson Imaging       Date:  1995       Impact factor: 2.546
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  30 in total

1.  Reduction kinetics and electrochemistry of tetracarboxylate nitroxides.

Authors:  Shengdian Huang; Hui Zhang; Joseph T Paletta; Suchada Rajca; Andrzej Rajca
Journal:  Free Radic Res       Date:  2018-02-27

2.  Imaging short-lived reactive oxygen species (ROS) with endogenous contrast MRI.

Authors:  Rong-Wen Tain; Alessandro M Scotti; Weiguo Li; Xiaohong Joe Zhou; Kejia Cai
Journal:  J Magn Reson Imaging       Date:  2017-05-15       Impact factor: 4.813

3.  Synthesis and reduction kinetics of sterically shielded pyrrolidine nitroxides.

Authors:  Joseph T Paletta; Maren Pink; Bridget Foley; Suchada Rajca; Andrzej Rajca
Journal:  Org Lett       Date:  2012-10-10       Impact factor: 6.005

4.  Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging.

Authors:  Molly A Sowers; Jessica R McCombs; Ying Wang; Joseph T Paletta; Stephen W Morton; Erik C Dreaden; Michael D Boska; M Francesca Ottaviani; Paula T Hammond; Andrzej Rajca; Jeremiah A Johnson
Journal:  Nat Commun       Date:  2014-11-18       Impact factor: 14.919

5.  PEGylated, Water-Soluble, Stable Aminyl Radical.

Authors:  Ying Wang; Suchada Rajca; Andrzej Rajca
Journal:  J Org Chem       Date:  2017-07-12       Impact factor: 4.354

6.  Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems.

Authors:  Hung V-T Nguyen; Alexandre Detappe; Peter Harvey; Nolan Gallagher; Clelia Mathieu; Michael P Agius; Oksana Zavidij; Wencong Wang; Yivan Jiang; Andrzej Rajca; Alan Jasanoff; Irene M Ghobrial; P Peter Ghoroghchian; Jeremiah A Johnson
Journal:  Polym Chem       Date:  2020-06-26       Impact factor: 5.582

7.  Intramolecular Hydrogen Atom Transfer in Aminyl Radical at Room Temperature with Large Kinetic Isotope Effect.

Authors:  Ying Wang; Arnon Olankitwanit; Suchada Rajca; Andrzej Rajca
Journal:  J Am Chem Soc       Date:  2017-05-22       Impact factor: 15.419

Review 8.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

9.  Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor.

Authors:  Madushani Dharmarwardana; André F Martins; Zhuo Chen; Philip M Palacios; Chance M Nowak; Raymond P Welch; Shaobo Li; Michael A Luzuriaga; Leonidas Bleris; Brad S Pierce; A Dean Sherry; Jeremiah J Gassensmith
Journal:  Mol Pharm       Date:  2018-05-29       Impact factor: 4.939

10.  Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging.

Authors:  Hung V-T Nguyen; Alexandre Detappe; Nolan M Gallagher; Hui Zhang; Peter Harvey; Changcun Yan; Clelia Mathieu; Matthew R Golder; Yivan Jiang; Maria Francesca Ottaviani; Alan Jasanoff; Andrzej Rajca; Irene Ghobrial; P Peter Ghoroghchian; Jeremiah A Johnson
Journal:  ACS Nano       Date:  2018-11-02       Impact factor: 15.881
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