BACKGROUND: The purpose of this study was to analyze the outcome of Australian patients treated for early lip cancer. METHODS: Data on 217 patients with T1 to T2 squamous cell carcinoma (SCC) of the lip and treated with radical intent were analyzed. RESULTS: The addition of local adjuvant radiotherapy in patients with a close/positive margin was associated with a significant improvement in relapse-free survival (RFS; p = .008). Tumor thickness (≤4 mm vs >4 mm) was also significantly associated with RFS (p = .01). The 5-year RFS was 51% after surgery, 87% after radiotherapy, and 92% after adjuvant radiotherapy. CONCLUSIONS: Patients with a tumor thickness >4 mm experienced an increased risk of recurrence, especially nodal. Compared with patients having any radiotherapy, those undergoing surgery experienced a higher rate of locoregional recurrence. The addition of adjuvant radiotherapy in patients with inadequate excision significantly decreased the risk of recurrence.
BACKGROUND: The purpose of this study was to analyze the outcome of Australian patients treated for early lip cancer. METHODS: Data on 217 patients with T1 to T2 squamous cell carcinoma (SCC) of the lip and treated with radical intent were analyzed. RESULTS: The addition of local adjuvant radiotherapy in patients with a close/positive margin was associated with a significant improvement in relapse-free survival (RFS; p = .008). Tumor thickness (≤4 mm vs >4 mm) was also significantly associated with RFS (p = .01). The 5-year RFS was 51% after surgery, 87% after radiotherapy, and 92% after adjuvant radiotherapy. CONCLUSIONS:Patients with a tumor thickness >4 mm experienced an increased risk of recurrence, especially nodal. Compared with patients having any radiotherapy, those undergoing surgery experienced a higher rate of locoregional recurrence. The addition of adjuvant radiotherapy in patients with inadequate excision significantly decreased the risk of recurrence.
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Authors: Kristin Lang; Sati Akbaba; Thomas Held; Rami El Shafie; Benjamin Farnia; Nina Bougatf; Denise Bernhardt; Christian Freudlsperger; Peter K Plinkert; Stefan Rieken; Jürgen Debus; Sebastian Adeberg Journal: Tumori Date: 2021-03-01 Impact factor: 2.098