OBJECTIVE: To assess prevalence, incidence, prognosis and progression of degenerative valvular aortic stenosis (AS). SETTING: The Tromsø Study and the University Hospital of North Norway. DESIGN: Population based prospective study. POPULATION: Over a 14 year span we performed three repeated echocardiographic examinations (1994, 2001 and 2008) of a random sample of initially 3273 participants. Data from the only hospital serving this population were included. RESULTS: There were 164 subjects with AS. Prevalence consistently increased with age, average values being 0.2% in the 50-59 year cohort, 1.3% in the 60-69 year cohort, 3.9% in the 70-79 year cohort and 9.8% in the 80-89 year cohort. The incidence rate in the study was 4.9‰/year. The mean annual increase in mean transvalvular pressure gradient was 3.2 mm Hg. The increase was lower in mild AS than in more severe disease, disclosing a non-linear development of the gradient, but with large individual variations. Mortality was not significantly increased in the asymptomatic AS-group (HR = 1.28), nor in those who received aortic valve replacement (n = 34, HR = 0.93), compared with the general population. CONCLUSION: This is the first study to document the incidence and prognosis of AS in a general population with surgery as a treatment option. It reveals an accelerated progression of the aortic mean gradient as the disease advances. The prognosis of AS seems to be comparable with the normal population in the asymptomatic stage and after successful surgery, indicating that the follow-up and timing of surgery has been adequate for this patient group.
OBJECTIVE: To assess prevalence, incidence, prognosis and progression of degenerative valvular aortic stenosis (AS). SETTING: The Tromsø Study and the University Hospital of North Norway. DESIGN: Population based prospective study. POPULATION: Over a 14 year span we performed three repeated echocardiographic examinations (1994, 2001 and 2008) of a random sample of initially 3273 participants. Data from the only hospital serving this population were included. RESULTS: There were 164 subjects with AS. Prevalence consistently increased with age, average values being 0.2% in the 50-59 year cohort, 1.3% in the 60-69 year cohort, 3.9% in the 70-79 year cohort and 9.8% in the 80-89 year cohort. The incidence rate in the study was 4.9‰/year. The mean annual increase in mean transvalvular pressure gradient was 3.2 mm Hg. The increase was lower in mild AS than in more severe disease, disclosing a non-linear development of the gradient, but with large individual variations. Mortality was not significantly increased in the asymptomatic AS-group (HR = 1.28), nor in those who received aortic valve replacement (n = 34, HR = 0.93), compared with the general population. CONCLUSION: This is the first study to document the incidence and prognosis of AS in a general population with surgery as a treatment option. It reveals an accelerated progression of the aortic mean gradient as the disease advances. The prognosis of AS seems to be comparable with the normal population in the asymptomatic stage and after successful surgery, indicating that the follow-up and timing of surgery has been adequate for this patient group.
Authors: Liv J Mundal; Anders Hovland; Jannicke Igland; Marit B Veierød; Kirsten B Holven; Martin Prøven Bogsrud; Grethe S Tell; Trond P Leren; Kjetil Retterstøl Journal: JAMA Cardiol Date: 2019-11-01 Impact factor: 14.676
Authors: Joanna L d'Arcy; Sean Coffey; Margaret A Loudon; Andrew Kennedy; Jonathan Pearson-Stuttard; Jacqueline Birks; Eleni Frangou; Andrew J Farmer; David Mant; Jo Wilson; Saul G Myerson; Bernard D Prendergast Journal: Eur Heart J Date: 2016-06-26 Impact factor: 29.983
Authors: Pavlo Yevtushenko; Florian Hellmeier; Jan Bruening; Sarah Nordmeyer; Volkmar Falk; Christoph Knosalla; Marcus Kelm; Titus Kuehne; Leonid Goubergrits Journal: Biophys J Date: 2019-07-22 Impact factor: 4.033
Authors: Aida Ribera; John Slof; Ignacio Ferreira-González; Vicente Serra; Bruno García-Del Blanco; Purificació Cascant; Rut Andrea; Carlos Falces; Enrique Gutiérrez; Raquel Del Valle-Fernández; César Morís-de laTassa; Pedro Mota; Juan Francisco Oteo; Pilar Tornos; David García-Dorado Journal: Eur J Health Econ Date: 2017-11-23
Authors: Shiying Liu; Jessica Churchill; Lanqi Hua; Xin Zeng; Valerie Rhoades; Mayooran Namasivayam; Vinit Baliyan; Brian B Ghoshhajra; Tony Dong; Jacob P Dal-Bianco; Jonathan J Passeri; Robert A Levine; Judy Hung Journal: J Am Soc Echocardiogr Date: 2020-04 Impact factor: 5.251