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Literature DB >> 22941789

Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging.

Matthew A Nakatsuka¹, Robert F Mattrey, Sadik C Esener, Jennifer N Cha, Andrew P Goodwin.

Abstract

Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 22941789 PMCID： PMC3626403 DOI： 10.1002/adma.201201484

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

20 in total

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Authors: Razvan Nutiu; Yingfu Li
Journal: J Am Chem Soc Date: 2003-04-23 Impact factor: 15.419

Review 2. Sonography of thrombosis of the deep veins of the extremities: clinical perspectives and imaging review.

Authors: Cher Heng Tan; Deepak Bedi; Raghunandan Vikram
Journal: J Clin Ultrasound Date: 2011-11-22 Impact factor: 0.910

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Authors: Joshua J Rychak; Jonathan R Lindner; Klaus Ley; Alexander L Klibanov
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Journal: Arterioscler Thromb Vasc Biol Date: 2002-11-01 Impact factor: 8.311

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Authors: Michael Nesheim
Journal: Chest Date: 2003-09 Impact factor: 9.410

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10. Perfluorocarbon-enhanced sonography: value in detecting acute venous thrombosis in rabbits.

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Journal: AJR Am J Roentgenol Date: 1994-10 Impact factor: 3.959

25 in total

1. Effect of Temperature on the Size Distribution, Shell Properties, and Stability of Definity^®.

Authors: Himanshu Shekhar; Nathaniel J Smith; Jason L Raymond; Christy K Holland
Journal: Ultrasound Med Biol Date: 2017-11-22 Impact factor: 2.998

2. Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles.

Authors: Igor Spivak; Anne Rix; Georg Schmitz; Stanley Fokong; Olga Iranzo; Wiltrud Lederle; Fabian Kiessling
Journal: Mol Imaging Biol Date: 2016-04 Impact factor: 3.488

Review 3. Applications of aptamers in targeted imaging: state of the art.

Authors: Casey A Dougherty; Weibo Cai; Hao Hong
Journal: Curr Top Med Chem Date: 2015 Impact factor: 3.295

4. Imparting the unique properties of DNA into complex material architectures and functions.

Authors: Phyllis F Xu; Hyunwoo Noh; Ju Hun Lee; Dylan W Domaille; Matthew A Nakatsuka; Andrew P Goodwin; Jennifer N Cha
Journal: Mater Today (Kidlington) Date: 2013-07 Impact factor: 31.041

5. Design and Application of Stimulus-Responsive Droplets and Bubbles Stabilized by Phospholipid Monolayers.

Authors: Rajarshi Chattaraj; Nicholas T Blum; Andrew P Goodwin
Journal: Curr Opin Colloid Interface Sci Date: 2018-10-21 Impact factor: 6.448

Review 6. Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy.

Authors: Xingshu Li; Jihoon Kim; Juyoung Yoon; Xiaoyuan Chen
Journal: Adv Mater Date: 2017-03-29 Impact factor: 30.849

Review 7. Current progress of aptamer-based molecular imaging.

Authors: Andrew Z Wang; Omid C Farokhzad
Journal: J Nucl Med Date: 2014-02-13 Impact factor: 10.057

8. Thrombin-Activatable Microbubbles as Potential Ultrasound Contrast Agents for the Detection of Acute Thrombosis.

Authors: Jacques Lux; Alexander M Vezeridis; Kenneth Hoyt; Stephen R Adams; Amanda M Armstrong; Shashank R Sirsi; Robert F Mattrey
Journal: ACS Appl Mater Interfaces Date: 2017-10-20 Impact factor: 9.229

9. In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive contrast agents.

Authors: Matthew A Nakatsuka; Christopher V Barback; Kirsten R Fitch; Alexander R Farwell; Sadik C Esener; Robert F Mattrey; Jennifer N Cha; Andrew P Goodwin
Journal: Biomaterials Date: 2013-09-10 Impact factor: 12.479

10. Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents.

Authors: Yijun Xie; Junxin Wang; James Wang; Ziying Hu; Ali Hariri; Nicholas Tu; Kelsey A Krug; Michael D Burkart; Nathan C Gianneschi; Jesse V Jokerst; Jeffrey D Rinehart
Journal: J Mater Chem B Date: 2019-08-07 Impact factor: 6.331