OBJECTIVE: We sought to evaluate the association between maternal medication use during pregnancy and cerebral white matter damage and cerebral palsy (CP) among very preterm infants. STUDY DESIGN: This analysis of data from the Extremely Low Gestational Age Newborns (ELGAN) Study included 877 infants born <28 weeks' gestation. Mothers were interviewed, charts were reviewed, placentas were cultured and assessed histologically, and children were evaluated at 24 months corrected age. A diagnostic algorithm classified neurologic findings as quadriparetic CP, diparetic CP, hemiparetic CP, or no CP. RESULTS: After adjustment for the potential confounding of disorders for which medications might have been indicated, the risk of quadriparetic CP remained elevated among the infants of mothers who consumed aspirin (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.3-6.9) and nonsteroidal antiinflammatory drugs (NSAIDs) (OR, 2.4; 95% CI, 1.04-5.8). The risk of diparetic CP was also associated with maternal consumption of an NSAID, but only if the consumption was not approved by a physician (OR, 3.5; 95% CI 1.1-11.0). CONCLUSION: The possibility that aspirin and NSAID use in pregnancy could lead to perinatal brain damage cannot be excluded.
OBJECTIVE: We sought to evaluate the association between maternal medication use during pregnancy and cerebral white matter damage and cerebral palsy (CP) among very preterm infants. STUDY DESIGN: This analysis of data from the Extremely Low Gestational Age Newborns (ELGAN) Study included 877 infants born <28 weeks' gestation. Mothers were interviewed, charts were reviewed, placentas were cultured and assessed histologically, and children were evaluated at 24 months corrected age. A diagnostic algorithm classified neurologic findings as quadriparetic CP, diparetic CP, hemiparetic CP, or no CP. RESULTS: After adjustment for the potential confounding of disorders for which medications might have been indicated, the risk of quadriparetic CP remained elevated among the infants of mothers who consumed aspirin (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.3-6.9) and nonsteroidal antiinflammatory drugs (NSAIDs) (OR, 2.4; 95% CI, 1.04-5.8). The risk of diparetic CP was also associated with maternal consumption of an NSAID, but only if the consumption was not approved by a physician (OR, 3.5; 95% CI 1.1-11.0). CONCLUSION: The possibility that aspirin and NSAID use in pregnancy could lead to perinatal brain damage cannot be excluded.
Authors: Jaclyn L F Bosco; Rebecca A Silliman; Soe Soe Thwin; Ann M Geiger; Diana S M Buist; Marianne N Prout; Marianne Ulcickas Yood; Reina Haque; Feifei Wei; Timothy L Lash Journal: J Clin Epidemiol Date: 2009-05-19 Impact factor: 6.437
Authors: Karl C K Kuban; Elizabeth N Allred; Michael O'Shea; Nigel Paneth; Marcello Pagano; Alan Leviton Journal: J Pediatr Date: 2008-06-02 Impact factor: 4.406
Authors: Jonathan L Hecht; Elizabeth N Allred; Harvey J Kliman; Eduardo Zambrano; Barbara J Doss; Aliya Husain; Solveig M V Pflueger; Chung-Ho Chang; Chad A Livasy; Drucilla Roberts; Ina Bhan; Dennis W Ross; Patricia Kaman Senagore; Alan Leviton Journal: Pathology Date: 2008-06 Impact factor: 5.306
Authors: Andrew B Onderdonk; Jonathan L Hecht; Thomas F McElrath; Mary L Delaney; Elizabeth N Allred; Alan Leviton Journal: Am J Obstet Gynecol Date: 2008-03-07 Impact factor: 8.661
Authors: T F McElrath; J L Hecht; O Dammann; K Boggess; A Onderdonk; G Markenson; M Harper; E Delpapa; E N Allred; A Leviton Journal: Am J Epidemiol Date: 2008-08-27 Impact factor: 4.897
Authors: Mari Holm; Michael E Msall; Jon Skranes; Olaf Dammann; Elizabeth Allred; Alan Leviton Journal: Eur J Paediatr Neurol Date: 2014-10-12 Impact factor: 3.140
Authors: Anuradha Phadke; Michael E Msall; Patrick Droste; Elizabeth N Allred; Thomas Michael O'Shea; Karl Kuban; Olaf Dammann; Alan Leviton Journal: Pediatr Neurol Date: 2014-03-15 Impact factor: 3.372