OBJECTIVE: The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation. STUDY DESIGN: Biopsy specimens of chorion parenchyma from 1083 placentas delivered before the beginning of the 28th week of gestation were cultured, and the placentas were examined histologically. The frequencies of individual microorganisms and groups of microorganisms were evaluated in strata of processes leading to preterm delivery, routes of delivery, gestational age, and placenta morphology. RESULTS: Placentas delivered by cesarean section with preeclampsia had the lowest bacterial recovery rate (25%). Preterm labor had the highest rates, which decreased with increasing gestational age from 79% at 23 weeks to 43% at 27 weeks. The presence of microorganisms in placenta parenchyma was associated with the presence of neutrophils in the fetal stem vessels of the chorion or in the vessels of the umbilical cord. CONCLUSION: The high rate of colonization appears to coincide with phenomena associated with preterm delivery and gestational age. The presence of microorganisms within placenta parenchyma is biologically important.
OBJECTIVE: The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation. STUDY DESIGN: Biopsy specimens of chorion parenchyma from 1083 placentas delivered before the beginning of the 28th week of gestation were cultured, and the placentas were examined histologically. The frequencies of individual microorganisms and groups of microorganisms were evaluated in strata of processes leading to preterm delivery, routes of delivery, gestational age, and placenta morphology. RESULTS: Placentas delivered by cesarean section with preeclampsia had the lowest bacterial recovery rate (25%). Preterm labor had the highest rates, which decreased with increasing gestational age from 79% at 23 weeks to 43% at 27 weeks. The presence of microorganisms in placenta parenchyma was associated with the presence of neutrophils in the fetal stem vessels of the chorion or in the vessels of the umbilical cord. CONCLUSION: The high rate of colonization appears to coincide with phenomena associated with preterm delivery and gestational age. The presence of microorganisms within placenta parenchyma is biologically important.
Authors: Helena Tlaskalová-Hogenová; Renata Stepánková; Tomás Hudcovic; Ludmila Tucková; Bozena Cukrowska; Rája Lodinová-Zádníková; Hana Kozáková; Pavel Rossmann; Jirina Bártová; Dan Sokol; David P Funda; Dana Borovská; Zuzana Reháková; Jirí Sinkora; Jaroslav Hofman; Pavel Drastich; Alena Kokesová Journal: Immunol Lett Date: 2004-05-15 Impact factor: 3.685
Authors: Andrew B Onderdonk; Mary L Delaney; Andrea M DuBois; Elizabeth N Allred; Alan Leviton Journal: Am J Obstet Gynecol Date: 2008-01 Impact factor: 8.661
Authors: Sunita Trivedi; Maria Joachim; Thomas McElrath; Harvey J Kliman; Elizabeth N Allred; Raina N Fichorova; Andrew Onderdonk; Fernanda Heitor; Leila Chaychi; Alan Leviton; Joseph A Majzoub Journal: Am J Obstet Gynecol Date: 2011-12-16 Impact factor: 8.661
Authors: Minghua L Chen; Elizabeth N Allred; Jonathan L Hecht; Andrew Onderdonk; Deborah VanderVeen; David K Wallace; Alan Leviton; Olaf Dammann Journal: Invest Ophthalmol Vis Sci Date: 2011-09-01 Impact factor: 4.799
Authors: Martha Scott Tomlinson; Kun Lu; Jill R Stewart; Carmen J Marsit; T Michael O'Shea; Rebecca C Fry Journal: Clin Microbiol Rev Date: 2019-05-01 Impact factor: 26.132
Authors: Alan Leviton; Karl Kuban; Elizabeth N Allred; Jonathan L Hecht; Andrew Onderdonk; T Michael O'Shea; Thomas McElrath; Nigel Paneth Journal: Early Hum Dev Date: 2010-07-31 Impact factor: 2.079
Authors: Christian Milani; Sabrina Duranti; Francesca Bottacini; Eoghan Casey; Francesca Turroni; Jennifer Mahony; Clara Belzer; Susana Delgado Palacio; Silvia Arboleya Montes; Leonardo Mancabelli; Gabriele Andrea Lugli; Juan Miguel Rodriguez; Lars Bode; Willem de Vos; Miguel Gueimonde; Abelardo Margolles; Douwe van Sinderen; Marco Ventura Journal: Microbiol Mol Biol Rev Date: 2017-11-08 Impact factor: 11.056