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Literature DB >> 22928775

Scaling the druggability landscape of human bromodomains, a new class of drug targets.

Guangtao Zhang¹, Roberto Sanchez, Ming-Ming Zhou.

Abstract

Entities: Chemical Disease Gene Species

Mesh：
Lysine/chemistry

Substances：
Lysine

Year: 2012 PMID： 22928775 PMCID： PMC3454531 DOI： 10.1021/jm3011977

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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38 in total

1. Structure and function of a human TAFII250 double bromodomain module.

Authors: R H Jacobson; A G Ladurner; D S King; R Tjian
Journal: Science Date: 2000-05-26 Impact factor: 47.728

Review 2. Bromodomain: an acetyl-lysine binding domain.

Authors: Lei Zeng; Ming Ming Zhou
Journal: FEBS Lett Date: 2002-02-20 Impact factor: 4.124

Review 3. The druggable genome.

Authors: Andrew L Hopkins; Colin R Groom
Journal: Nat Rev Drug Discov Date: 2002-09 Impact factor: 84.694

4. Selective small molecules blocking HIV-1 Tat and coactivator PCAF association.

Authors: Lei Zeng; Jiaming Li; Michaela Muller; Sherry Yan; Shiraz Mujtaba; Chongfeng Pan; Zhiyong Wang; Ming-Ming Zhou
Journal: J Am Chem Soc Date: 2005-03-02 Impact factor: 15.419

5. The druggable genome: an update.

Authors: Andreas P Russ; Stefan Lampel
Journal: Drug Discov Today Date: 2005-12 Impact factor: 7.851

Review 6. Predicting protein druggability.

Authors: Philip J Hajduk; Jeffrey R Huth; Christin Tse
Journal: Drug Discov Today Date: 2005-12 Impact factor: 7.851

7. Structure and ligand of a histone acetyltransferase bromodomain.

Authors: C Dhalluin; J E Carlson; L Zeng; C He; A K Aggarwal; M M Zhou
Journal: Nature Date: 1999-06-03 Impact factor: 49.962

8. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association.

Authors: Lois Resnick-Silverman; Sherry Yan; Shiraz Mutjaba; Wen-Jun Liu; Lei Zeng; James J Manfredi; Ming-Ming Zhou
Journal: Chem Biol Date: 2006-01

9. The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p.

Authors: D J Owen; P Ornaghi; J C Yang; N Lowe; P R Evans; P Ballario; D Neuhaus; P Filetici; A A Travers
Journal: EMBO J Date: 2000-11-15 Impact factor: 11.598

Review 10. A leap into the chemical space of protein-protein interaction inhibitors.

Authors: B O Villoutreix; C M Labbé; D Lagorce; G Laconde; O Sperandio
Journal: Curr Pharm Des Date: 2012 Impact factor: 3.116

8 in total

Review 1. The bromodomain: from epigenome reader to druggable target.

Authors: Roberto Sanchez; Jamel Meslamani; Ming-Ming Zhou
Journal: Biochim Biophys Acta Date: 2014-03-28

Review 2. Partners in crime: The role of tandem modules in gene transcription.

Authors: Rajal Sharma; Ming-Ming Zhou
Journal: Protein Sci Date: 2015-06-11 Impact factor: 6.725

Review 3. Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs.

Authors: Mohd Muddassir; Kunjal Soni; Chetan B Sangani; Abdullah Alarifi; Mohd Afzal; Naaser A Y Abduh; Yongtao Duan; Poonam Bhadja
Journal: RSC Adv Date: 2020-12-24 Impact factor: 4.036