Literature DB >> 16376820

The druggable genome: an update.

Andreas P Russ1, Stefan Lampel.   

Abstract

Annotating the druggable genome estimates the potential maximum size of the playing field for current small-molecule drug design but It does not consider biologicals or future breakthroughs in medicinal chemistry or biology.

Mesh：

Substances：

Year:  2005        PMID： 16376820     DOI： 10.1016/S1359-6446(05)03666-4

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  131 in total

1.  Molecular simulation methods in drug discovery: a prospective outlook.

Authors:  Xavier Barril; F Javier Luque
Journal:  J Comput Aided Mol Des       Date:  2011-12-08       Impact factor: 3.686

Review 2.  Diagnosing the decline in pharmaceutical R&D efficiency.

Authors:  Jack W Scannell; Alex Blanckley; Helen Boldon; Brian Warrington
Journal:  Nat Rev Drug Discov       Date:  2012-03-01       Impact factor: 84.694

Review 3.  PubChem as a public resource for drug discovery.

Authors:  Qingliang Li; Tiejun Cheng; Yanli Wang; Stephen H Bryant
Journal:  Drug Discov Today       Date:  2010-10-21       Impact factor: 7.851

4.  Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.

Authors:  Xun Shang; Fillipo Marchioni; Nisha Sipes; Chris R Evelyn; Moran Jerabek-Willemsen; Stefan Duhr; William Seibel; Matthew Wortman; Yi Zheng
Journal:  Chem Biol       Date:  2012-06-22

5.  How chemoproteomics can enable drug discovery and development.

Authors:  Raymond E Moellering; Benjamin F Cravatt
Journal:  Chem Biol       Date:  2012-01-27

Review 6.  Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders.

Authors:  Yu Chen; Krzysztof Palczewski
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-03-23       Impact factor: 13.820

Review 7.  Ligand discovery and virtual screening using the program LIDAEUS.

Authors:  P Taylor; E Blackburn; Y G Sheng; S Harding; K-Y Hsin; D Kan; S Shave; M D Walkinshaw
Journal:  Br J Pharmacol       Date:  2007-11-26       Impact factor: 8.739

Review 8.  Chemogenomic approaches to rational drug design.

Authors:  D Rognan
Journal:  Br J Pharmacol       Date:  2007-05-29       Impact factor: 8.739

9.  Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.

Authors:  Xun Shang; Fillipo Marchioni; Chris R Evelyn; Nisha Sipes; Xuan Zhou; William Seibel; Matthew Wortman; Yi Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

10.  Drug target predictions based on heterogeneous graph inference.

Authors:  Wenhui Wang; Sen Yang; Jing Li
Journal:  Pac Symp Biocomput       Date:  2013
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