Literature DB >> 26086019

Development of gene and stem cell therapy for ocular neurodegeneration.

Jing-Xue Zhang1, Ning-Li Wang1, Qing-Jun Lu1.   

Abstract

Retinal degenerative diseases pose a serious threat to eye health, but there is currently no effective treatment available. Recent years have witnessed rapid development of several cutting-edge technologies, such as gene therapy, stem cell therapy, and tissue engineering. Due to the special features of ocular structure, some of these technologies have been translated into ophthalmological clinic practice with fruitful achievements, setting a good example for other fields. This paper reviews the development of the gene and stem cell therapies in ophthalmology.

Entities:  

Keywords:  gene therapy; retina; stem cell; translational medicine

Year:  2015        PMID： 26086019      PMCID： PMC4458674          DOI： 10.3980/j.issn.2222-3959.2015.03.33

Source DB:  PubMed          Journal:  Int J Ophthalmol        ISSN： 2222-3959            Impact factor:   1.779


  66 in total

1.  Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer.

Authors:  Hiroshi Tomita; Eriko Sugano; Hiromu Yawo; Toru Ishizuka; Hitomi Isago; Satoko Narikawa; Sebastian Kügler; Makoto Tamai
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-08       Impact factor: 4.799

2.  Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.

Authors:  David E Buchholz; Britney O Pennington; Roxanne H Croze; Cassidy R Hinman; Peter J Coffey; Dennis O Clegg
Journal:  Stem Cells Transl Med       Date:  2013-04-18       Impact factor: 6.940

3.  Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype-phenotype correlations and impact on genetic counseling.

Authors:  Valérie Pelletier; Marguerite Jambou; Nathalie Delphin; Elena Zinovieva; Morgane Stum; Nadine Gigarel; Hélène Dollfus; Christian Hamel; Annick Toutain; Jean-Louis Dufier; Olivier Roche; Arnold Munnich; Jean-Paul Bonnefont; Josseline Kaplan; Jean-Michel Rozet
Journal:  Hum Mutat       Date:  2007-01       Impact factor: 4.878

4.  Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys.

Authors:  Chooi-May Lai; Wei-Yong Shen; Meliha Brankov; Yvonne K Y Lai; Nigel L Barnett; Shu-Yen Lee; Ian Y S Yeo; Ranjana Mathur; Joseph E S Ho; Paul Pineda; Amutha Barathi; Chong-Lye Ang; Ian J Constable; Elizabeth P Rakoczy
Journal:  Mol Ther       Date:  2005-10       Impact factor: 11.454

5.  Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity.

Authors:  S Hattar; H W Liao; M Takao; D M Berson; K W Yau
Journal:  Science       Date:  2002-02-08       Impact factor: 47.728

6.  Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells.

Authors:  David E Buchholz; Sherry T Hikita; Teisha J Rowland; Amy M Friedrich; Cassidy R Hinman; Lincoln V Johnson; Dennis O Clegg
Journal:  Stem Cells       Date:  2009-10       Impact factor: 6.277

7.  Transplantation of tissue-engineered retinal pigment epithelial cell sheets in a rabbit model.

Authors:  Naoko Yaji; Masayuki Yamato; Joseph Yang; Teruo Okano; Sadao Hori
Journal:  Biomaterials       Date:  2008-11-25       Impact factor: 12.479

8.  Impact of retinal disease-associated RPE65 mutations on retinoid isomerization.

Authors:  Grzegorz Bereta; Philip D Kiser; Marcin Golczak; Wenyu Sun; Elise Heon; David A Saperstein; Krzysztof Palczewski
Journal:  Biochemistry       Date:  2008-08-23       Impact factor: 3.162

9.  Restoration of vision after transplantation of photoreceptors.

Authors:  R A Pearson; A C Barber; M Rizzi; C Hippert; T Xue; E L West; Y Duran; A J Smith; J Z Chuang; S A Azam; U F O Luhmann; A Benucci; C H Sung; J W Bainbridge; M Carandini; K-W Yau; J C Sowden; R R Ali
Journal:  Nature       Date:  2012-05-03       Impact factor: 49.962

10.  Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B.

Authors:  T Hashimoto; D Gibbs; C Lillo; S M Azarian; E Legacki; X-M Zhang; X-J Yang; D S Williams
Journal:  Gene Ther       Date:  2007-02-01       Impact factor: 4.184
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  2 in total

1.  Sustained Release of Gas6 via mPEG-PLGA Nanoparticles Enhances the Therapeutic Effects of MERTK Gene Therapy in RCS Rats.

Authors:  Shen Wu; Yingyan Mao; Qian Liu; Xuejing Yan; Jingxue Zhang; Ningli Wang
Journal:  Front Med (Lausanne)       Date:  2021-12-14

Review 2.  Advancing precision medicines for ocular disorders: Diagnostic genomics to tailored therapies.

Authors:  Priyalakshmi Panikker; Shomereeta Roy; Anuprita Ghosh; B Poornachandra; Arkasubhra Ghosh
Journal:  Front Med (Lausanne)       Date:  2022-07-15
  2 in total

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