Literature DB >> 22922345

Qinghaosu (artemisinin): chemistry and pharmacology.

Ying Li1.   

Abstract

Qinghaosu and its derivatives are widely used in the world as a new generation of antimalarial drug. Up to now, some important progresses of Qinghaosu research have been made, including synthesis of new qinghaosu derivatives and analogs, investigation on their bioactivities and mode of actions. The present review briefly describes these efforts made by researchers in China, particularly in this Institute.

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Year:  2012        PMID: 22922345      PMCID: PMC4003104          DOI: 10.1038/aps.2012.104

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN: 1671-4083            Impact factor:   6.150


  45 in total

1.  Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle.

Authors:  Y Li; F Shan; J M Wu; G S Wu; J Ding; D Xiao; W Y Yang; G Atassi; S Léonce; D H Caignard; P Renard
Journal:  Bioorg Med Chem Lett       Date:  2001-01-08       Impact factor: 2.823

2.  [Antitumor activities of 4 derivatives of artemisic acid and artemisinin B in vitro].

Authors:  W C Sun; J X Han; W Y Yang; D A Deng; X F Yue
Journal:  Zhongguo Yao Li Xue Bao       Date:  1992-11

3.  Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum.

Authors:  Yungen Liu; Chun-Nam Lok; Ben Chi-Bun Ko; Tina Yuen-Ting Shum; Man-Kin Wong; Chi-Ming Che
Journal:  Org Lett       Date:  2010-04-02       Impact factor: 6.005

4.  Antimalarial efficacy and mode of action of qinghaosu and its derivatives in experimental models. China Cooperative Research Group on qinghaosu and its derivatives as antimalarials.

Authors: 
Journal:  J Tradit Chin Med       Date:  1982-03       Impact factor: 0.848

5.  Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.

Authors:  Jin-Jian Lu; Ling-Hua Meng; Uma T Shankavaram; Cai-Hua Zhu; Lin-Jiang Tong; Guang Chen; Li-Ping Lin; John N Weinstein; Jian Ding
Journal:  Biochem Pharmacol       Date:  2010-03-03       Impact factor: 5.858

Review 6.  Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action.

Authors:  C W Jefford
Journal:  Curr Med Chem       Date:  2001-12       Impact factor: 4.530

7.  Study on the mechanism of action of artemether against schistosomes: the identification of cysteine adducts of both carbon-centred free radicals derived from artemether.

Authors:  Wen-Min Wu; Yan-Li Chen; Zili Zhai; Shu-Hua Xiao; Yu-Lin Wu
Journal:  Bioorg Med Chem Lett       Date:  2003-05-19       Impact factor: 2.823

8.  Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species.

Authors:  Jin-Jian Lu; Ling-Hua Meng; Yu-Jun Cai; Qin Chen; Lin-Jiang Tong; Li-Ping Lin; Jian Ding
Journal:  Cancer Biol Ther       Date:  2008-04-04       Impact factor: 4.742

9.  Molecular docking and 3-D-QSAR studies on the possible antimalarial mechanism of artemisinin analogues.

Authors:  Feng Cheng; Jianhua Shen; Xiaomin Luo; Weiliang Zhu; Jiande Gu; Ruyun Ji; Hualiang Jiang; Kaixian Chen
Journal:  Bioorg Med Chem       Date:  2002-09       Impact factor: 3.641

Review 10.  Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug.

Authors:  Maria P Crespo-Ortiz; Ming Q Wei
Journal:  J Biomed Biotechnol       Date:  2011-11-22
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  33 in total

1.  Celebrating the 80th anniversary of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM).

Authors:  Jian Ding
Journal:  Acta Pharmacol Sin       Date:  2012-09       Impact factor: 6.150

Review 2.  Immune suppressive properties of artemisinin family drugs.

Authors:  Lifei Hou; Haochu Huang
Journal:  Pharmacol Ther       Date:  2016-07-10       Impact factor: 12.310

3.  Dihydroartemisinin-induced apoptosis in human acute monocytic leukemia cells.

Authors:  Jia-Tian Cao; Hui-Min Mo; Yue Wang; Kai Zhao; Tian-Tian Zhang; Chang-Qian Wang; Kai-Lin Xu; Zhi-Hua Han
Journal:  Oncol Lett       Date:  2017-12-19       Impact factor: 2.967

Review 4.  Artemisinin and its derivatives: a potential therapeutic approach for oral lichen planus.

Authors:  Rui-Jie Ma; Ming-Jing He; Ya-Qin Tan; Gang Zhou
Journal:  Inflamm Res       Date:  2019-02-01       Impact factor: 4.575

5.  Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway.

Authors:  Min Lu; Luhaoran Sun; Jin Zhou; Jing Yang
Journal:  Tumour Biol       Date:  2014-02-12

6.  Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells.

Authors:  Yoshinobu Odaka; Baoshan Xu; Yan Luo; Tao Shen; Chaowei Shang; Yang Wu; Hongyu Zhou; Shile Huang
Journal:  Carcinogenesis       Date:  2013-08-08       Impact factor: 4.944

7.  Activation of artemisinin and heme degradation in Leishmania tarentolae promastigotes: A possible link.

Authors:  Gerald Geroldinger; Matthias Tonner; Judith Quirgst; Martin Walter; Sritama De Sarkar; Laura Machín; Lianet Monzote; Klaus Stolze; J Catharina Duvigneau; Katrin Staniek; Mitali Chatterjee; Lars Gille
Journal:  Biochem Pharmacol       Date:  2019-11-29       Impact factor: 5.858

8.  Formulation and evaluation of transdermal nanogel for delivery of artemether.

Authors:  Petra O Nnamani; Agatha A Ugwu; Ogechukwu H Nnadi; Franklin C Kenechukwu; Kenneth C Ofokansi; Anthony A Attama; Claus-Michael Lehr
Journal:  Drug Deliv Transl Res       Date:  2021-03-19       Impact factor: 4.617

9.  Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets.

Authors:  Zemin Lin; Yuting Liu; Li Chen; Shiqi Cao; Yueteng Huang; Xiaoqian Yang; Fenghua Zhu; Wei Tang; Shijun He; Jianping Zuo
Journal:  Sci China Life Sci       Date:  2021-01-19       Impact factor: 6.038

10.  Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells.

Authors:  Jun Luo; Yoshinobu Odaka; Zhu Huang; Bing Cheng; Wang Liu; Lin Li; Chaowei Shang; Chao Zhang; Yang Wu; Yan Luo; Shengyong Yang; Peter J Houghton; Xiaofeng Guo; Shile Huang
Journal:  Cells       Date:  2021-06-01       Impact factor: 7.666

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