Literature DB >> 20192248

Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum.

Yungen Liu1, Chun-Nam Lok, Ben Chi-Bun Ko, Tina Yuen-Ting Shum, Man-Kin Wong, Chi-Ming Che.   

Abstract

A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.

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Year:  2010        PMID： 20192248     DOI： 10.1021/ol902890j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  20 in total

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Review 9.  Plasmodium falciparum: multifaceted resistance to artemisinins.

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