| Literature DB >> 11140731 |
Y Li1, F Shan, J M Wu, G S Wu, J Ding, D Xiao, W Y Yang, G Atassi, S Léonce, D H Caignard, P Renard.
Abstract
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis.Entities:
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Year: 2001 PMID： 11140731 DOI： 10.1016/s0960-894x(00)00578-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823