Literature DB >> 22911103

Epigenetics meets mathematics: towards a quantitative understanding of chromatin biology.

Philipp A Steffen1, João P Fonseca, Leonie Ringrose.   

Abstract

How fast? How strong? How many? So what? Why do numbers matter in biology? Chromatin binding proteins are forever in motion, exchanging rapidly between bound and free pools. How do regulatory systems whose components are in constant flux ensure stability and flexibility? This review explores the application of quantitative and mathematical approaches to mechanisms of epigenetic regulation. We discuss methods for measuring kinetic parameters and protein quantities in living cells, and explore the insights that have been gained by quantifying and modelling dynamics of chromatin binding proteins.
Copyright © 2012 WILEY Periodicals, Inc.

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Year:  2012        PMID： 22911103     DOI： 10.1002/bies.201200076

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  14 in total

Review 1.  What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.

Authors:  Philipp A Steffen; Leonie Ringrose
Journal:  Nat Rev Mol Cell Biol       Date:  2014-05       Impact factor: 94.444

Review 2.  Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism.

Authors:  Daphne S Cabianca; Susan M Gasser
Journal:  Nucleus       Date:  2016-05-03       Impact factor: 4.197

3.  Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities.

Authors:  Farah Bughio; Gary R Huckell; Keith A Maggert
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-16       Impact factor: 11.205

4.  The ATAD2 bromodomain binds different acetylation marks on the histone H4 in similar fuzzy complexes.

Authors:  Cassiano Langini; Amedeo Caflisch; Andreas Vitalis
Journal:  J Biol Chem       Date:  2017-08-10       Impact factor: 5.157

5.  Vernalizing cold is registered digitally at FLC.

Authors:  Andrew Angel; Jie Song; Hongchun Yang; Julia I Questa; Caroline Dean; Martin Howard
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-16       Impact factor: 11.205

6.  Multivalency governs HP1α association dynamics with the silent chromatin state.

Authors:  Sinan Kilic; Andreas L Bachmann; Louise C Bryan; Beat Fierz
Journal:  Nat Commun       Date:  2015-06-18       Impact factor: 14.919

7.  Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing.

Authors:  Vijayalakshmi H Nagaraj; Swagatam Mukhopadhyay; Adel Dayarian; Anirvan M Sengupta
Journal:  PLoS One       Date:  2014-12-23       Impact factor: 3.240

8.  Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

Authors:  Iris J E Stulemeijer; Dirk De Vos; Kirsten van Harten; Onkar K Joshi; Olga Blomberg; Tibor van Welsem; Marit Terweij; Hanneke Vlaming; Erik L de Graaf; A F Maarten Altelaar; Barbara M Bakker; Fred van Leeuwen
Journal:  Sci Rep       Date:  2015-05-12       Impact factor: 4.379

9.  Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae.

Authors:  Kim Sneppen; Ian B Dodd
Journal:  Epigenetics       Date:  2015-04-01       Impact factor: 4.528

10.  Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin.

Authors:  Philipp A Steffen; João Pedro Fonseca; Cornelia Gänger; Eva Dworschak; Tobias Kockmann; Christian Beisel; Leonie Ringrose
Journal:  Nucleic Acids Res       Date:  2013-04-10       Impact factor: 16.971
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