Literature DB >> 22908094

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window.

Erin Wachter1, David K Heidary, Brock S Howerton, Sean Parkin, Edith C Glazer.   

Abstract

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

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Year:  2012        PMID： 22908094     DOI： 10.1039/c2cc33359g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  51 in total

1.  New Ru(II) Complex for Dual Activity: Photoinduced Ligand Release and (1)O2 Production.

Authors:  Lauren M Loftus; Jessica K White; Bryan A Albani; Lars Kohler; Jeremy J Kodanko; Randolph P Thummel; Kim R Dunbar; Claudia Turro
Journal:  Chemistry       Date:  2016-01-20       Impact factor: 5.236

2.  Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.

Authors:  Jessica D Knoll; Claudia Turro
Journal:  Coord Chem Rev       Date:  2015-01-01       Impact factor: 22.315

3.  An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy.

Authors:  Jessica K White; Russell H Schmehl; Claudia Turro
Journal:  Inorganica Chim Acta       Date:  2016-06-18       Impact factor: 2.545

4.  Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex.

Authors:  Joshua J Woods; Jian Cao; Alexander R Lippert; Justin J Wilson
Journal:  J Am Chem Soc       Date:  2018-09-19       Impact factor: 15.419

5.  Dual Photoreactivity of a New Rh2(II,II) Complex for Biological Applications.

Authors:  Regina N Akhimie; Jessica K White; Claudia Turro
Journal:  Inorganica Chim Acta       Date:  2016-04-18       Impact factor: 2.545

6.  New Ru(II) complexes for dual photoreactivity: ligand exchange and (1)O2 generation.

Authors:  Jessica D Knoll; Bryan A Albani; Claudia Turro
Journal:  Acc Chem Res       Date:  2015-07-17       Impact factor: 22.384

7.  Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands.

Authors:  Christian Reichardt; Susan Monro; Fabian H Sobotta; Katsuya L Colón; Tariq Sainuddin; Mat Stephenson; Eric Sampson; John Roque; Huimin Yin; Johannes C Brendel; Colin G Cameron; Sherri McFarland; Benjamin Dietzek
Journal:  Inorg Chem       Date:  2019-02-14       Impact factor: 5.165

8.  A new class of Ru(II) polyazine agents with potential for photodynamic therapy.

Authors:  Roberto Padilla; José A Rodriguez-Corrales; Lauren E Donohoe; Brenda S J Winkel; Karen J Brewer
Journal:  Chem Commun (Camb)       Date:  2016-02-14       Impact factor: 6.222

9.  Photochemical Properties and Structure-Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents.

Authors:  Dmytro Havrylyuk; David K Heidary; Leona Nease; Sean Parkin; Edith C Glazer
Journal:  Eur J Inorg Chem       Date:  2017-02-15       Impact factor: 2.524

10.  Excited state investigation of a new Ru(II) complex for dual reactivity with low energy light.

Authors:  J D Knoll; B A Albani; C Turro
Journal:  Chem Commun (Camb)       Date:  2015-05-25       Impact factor: 6.222
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