Literature DB >> 26756042

A new class of Ru(II) polyazine agents with potential for photodynamic therapy.

Roberto Padilla1, José A Rodriguez-Corrales1, Lauren E Donohoe1, Brenda S J Winkel2, Karen J Brewer1.   

Abstract

Appending anthracene units to [(bpy)2Ru(dpp)](2+) results in Ru(II) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)](2+) and [(Anthbpy)2Ru(dpp)](2+) are the first metal-organic Ru(II) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner.

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Year:  2016        PMID： 26756042      PMCID： PMC4819402          DOI： 10.1039/c5cc08682e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  33 in total

Review 1.  More than one way to die: apoptosis, necrosis and reactive oxygen damage.

Authors:  W Fiers; R Beyaert; W Declercq; P Vandenabeele
Journal:  Oncogene       Date:  1999-12-16       Impact factor: 9.867

2.  Photocleavage of Nucleic Acids.

Authors:  Bruce Armitage
Journal:  Chem Rev       Date:  1998-05-07       Impact factor: 60.622

Review 3.  Formation and repair of interstrand cross-links in DNA.

Authors:  David M Noll; Tracey McGregor Mason; Paul S Miller
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

4.  Binding of anthracene to cellular macromolecules in the presence of light.

Authors:  B K Sinha; C F Chignell
Journal:  Photochem Photobiol       Date:  1983-01       Impact factor: 3.421

5.  Ru(II) dyads derived from 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: versatile photosensitizers for photodynamic applications.

Authors:  Mat Stephenson; Christian Reichardt; Mitch Pinto; Maria Wächtler; Tariq Sainuddin; Ge Shi; Huimin Yin; Susan Monro; Eric Sampson; Benjamin Dietzek; Sherri A McFarland
Journal:  J Phys Chem A       Date:  2014-07-01       Impact factor: 2.781

6.  Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window.

Authors:  Erin Wachter; David K Heidary; Brock S Howerton; Sean Parkin; Edith C Glazer
Journal:  Chem Commun (Camb)       Date:  2012-10-07       Impact factor: 6.222

7.  Enhanced DNA photocleavage properties of Ru(II) terpyridine complexes upon incorporation of methylphenyl substituted terpyridine and/or the polyazine bridging ligand dpp (2,3-bis(2-pyridyl)pyrazine).

Authors:  Avijita Jain; Carla Slebodnick; Brenda S J Winkel; Karen J Brewer
Journal:  J Inorg Biochem       Date:  2008-06-20       Impact factor: 4.155

Review 8.  Singlet oxygen-mediated damage to proteins and its consequences.

Authors:  Michael J Davies
Journal:  Biochem Biophys Res Commun       Date:  2003-06-06       Impact factor: 3.575

9.  Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy.

Authors:  Huaiyi Huang; Bole Yu; Pingyu Zhang; Juanjuan Huang; Yu Chen; Gilles Gasser; Liangnian Ji; Hui Chao
Journal:  Angew Chem Int Ed Engl       Date:  2015-10-08       Impact factor: 15.336

10.  Metal bacteriochlorins which act as dual singlet oxygen and superoxide generators.

Authors:  Shunichi Fukuzumi; Kei Ohkubo; Xiang Zheng; Yihui Chen; Ravindra K Pandey; Riqiang Zhan; Karl M Kadish
Journal:  J Phys Chem B       Date:  2008-02-07       Impact factor: 2.991
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  1 in total

Review 1.  Transition Metal Intercalators as Anticancer Agents-Recent Advances.

Authors:  Krishant M Deo; Benjamin J Pages; Dale L Ang; Christopher P Gordon; Janice R Aldrich-Wright
Journal:  Int J Mol Sci       Date:  2016-10-31       Impact factor: 5.923
  1 in total

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