Literature DB >> 30230336

Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex.

Joshua J Woods1,2, Jian Cao3, Alexander R Lippert3, Justin J Wilson2.   

Abstract

Hydrogen sulfide (H2S) is a biological gasotransmitter that has been employed for the treatment of ischemia-reperfusion injury. Despite its therapeutic value, the implementation of this gaseous molecule for this purpose has required H2S-releasing prodrugs for effective intracellular delivery. The majority of these prodrugs, however, spontaneously release H2S via uncontrolled hydrolysis. Here, we describe a Ru(II)-based H2S-releasing agent that can be activated selectively by red light irradiation. This compound operates in living cells, increasing intracellular H2S concentration only upon irradiation with red light. Furthermore, the red light irradiation of this compound protects H9c2 cardiomyoblasts from an in vitro model of ischemia-reperfusion injury. These results validate the use of red light-activated H2S-releasing agents as valuable tools for studying the biology and therapeutic utility of this gasotransmitter.

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Year:  2018        PMID： 30230336      PMCID： PMC6599746          DOI： 10.1021/jacs.8b08695

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  60 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-08       Impact factor: 11.205

2.  The neuroprotection of hydrogen sulfide against MPTP-induced dopaminergic neuron degeneration involves uncoupling protein 2 rather than ATP-sensitive potassium channels.

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3.  Hydrogen Sulfide Donors Activated by Reactive Oxygen Species.

Authors:  Yu Zhao; Michael D Pluth
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-24       Impact factor: 15.336

4.  Development of photo-controllable hydrogen sulfide donor applicable in live cells.

Authors:  Naoki Fukushima; Naoya Ieda; Mitsuyasu Kawaguchi; Kiyoshi Sasakura; Tetsuo Nagano; Kenjiro Hanaoka; Naoki Miyata; Hidehiko Nakagawa
Journal:  Bioorg Med Chem Lett       Date:  2014-12-08       Impact factor: 2.823

5.  Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.

Authors:  John W Elrod; John W Calvert; Joanna Morrison; Jeannette E Doeller; David W Kraus; Ling Tao; Xiangying Jiao; Rosario Scalia; Levente Kiss; Csaba Szabo; Hideo Kimura; Chi-Wing Chow; David J Lefer
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-18       Impact factor: 11.205

6.  Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production.

Authors:  Vivian S Lin; Alexander R Lippert; Christopher J Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-15       Impact factor: 11.205

7.  The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress.

Authors:  Lara Testai; Alice Marino; Ilaria Piano; Vincenzo Brancaleone; Kengo Tomita; Lorenzo Di Cesare Mannelli; Alma Martelli; Valentina Citi; Maria C Breschi; Roberto Levi; Claudia Gargini; Mariarosaria Bucci; Giuseppe Cirino; Carla Ghelardini; Vincenzo Calderone
Journal:  Pharmacol Res       Date:  2016-09-09       Impact factor: 7.658

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Authors:  Jessica D Knoll; Bryan A Albani; Christopher B Durr; Claudia Turro
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9.  An in vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines.

Authors:  S L Hopkins; B Siewert; S H C Askes; P Veldhuizen; R Zwier; Michal Heger; Sylvestre Bonnet
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10.  Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health.

Authors:  James J DiNicolantonio; James H OKeefe; Mark F McCarty
Journal:  Open Heart       Date:  2017-05-22
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  11 in total

1.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

Review 2.  Activatable Small-Molecule Hydrogen Sulfide Donors.

Authors:  Carolyn M Levinn; Matthew M Cerda; Michael D Pluth
Journal:  Antioxid Redox Signal       Date:  2019-10-29       Impact factor: 8.401

3.  Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways.

Authors:  Yu Zhao; Andrea K Steiger; Michael D Pluth
Journal:  J Am Chem Soc       Date:  2019-08-14       Impact factor: 15.419

4.  Dithioesters: simple, tunable, cysteine-selective H2S donors.

Authors:  Matthew M Cerda; Turner D Newton; Yu Zhao; Brylee K Collins; Christopher H Hendon; Michael D Pluth
Journal:  Chem Sci       Date:  2018-11-30       Impact factor: 9.825

5.  Antibacterial Activity of Amidodithiophosphonato Nickel(II) Complexes: An Experimental and Theoretical Approach.

Authors:  Enrico Podda; Massimiliano Arca; Giulia Atzeni; Simon J Coles; Antonella Ibba; Francesco Isaia; Vito Lippolis; Germano Orrù; James B Orton; Anna Pintus; Enrica Tuveri; M Carla Aragoni
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411

6.  Light-activated gold nanorod vesicles with NIR-II fluorescence and photoacoustic imaging performances for cancer theranostics.

Authors:  Xiaoguang Ge; Qinrui Fu; Lichao Su; Zhi Li; Wenmin Zhang; Tao Chen; Huanghao Yang; Jibin Song
Journal:  Theranostics       Date:  2020-03-26       Impact factor: 11.556

7.  Reactive oxygen species-triggered off-on fluorescence donor for imaging hydrogen sulfide delivery in living cells.

Authors:  Yiming Hu; Xiaoyi Li; Yu Fang; Wen Shi; Xiaohua Li; Wei Chen; Ming Xian; Huimin Ma
Journal:  Chem Sci       Date:  2019-07-10       Impact factor: 9.825

8.  Photorelease of a metal-binding pharmacophore from a Ru(II) polypyridine complex.

Authors:  Johannes Karges; Ryjul W Stokes; Seth M Cohen
Journal:  Dalton Trans       Date:  2021-03-02       Impact factor: 4.390

9.  Biocompatible metal-organic frameworks for the storage and therapeutic delivery of hydrogen sulfide.

Authors:  Faith E Chen; Ruth M Mandel; Joshua J Woods; Jung-Hoon Lee; Jaehwan Kim; Jesse H Hsu; José J Fuentes-Rivera; Justin J Wilson; Phillip J Milner
Journal:  Chem Sci       Date:  2021-04-30       Impact factor: 9.969

10.  A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2 S) Donor.

Authors:  Joshua J Woods; Justin J Wilson
Journal:  Angew Chem Int Ed Engl       Date:  2020-11-16       Impact factor: 15.336
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