| Literature DB >> 22903274 |
Neda Jahanshad1, Omid Kohannim, Arthur W Toga, Katie L McMahon, Greig I de Zubicaray, Narelle K Hansell, Grant W Montgomery, Nicholas G Martin, Margaret J Wright, Paul M Thompson.
Abstract
Large multi-site image-analysis studies have successfully discovered genetic variants that affect brain structure in tens of thousands of subjects scanned worldwide. Candidate genes have also associated with brain integrity, measured using fractional anisotropy in diffusion tensor images (DTI). To evaluate the heritability and robustness of DTI measures as a target for genetic analysis, we compared 417 twins and siblings scanned on the same day on the same high field scanner (4-Tesla) with two protocols: (1) 94-directions; 2mm-thick slices, (2) 27-directions; 5mm-thickness. Using mean FA in white matter ROIs and FA 'skeletons' derived using FSL, we (1) examined differences in voxelwise means, variances, and correlations among the measures; and (2) assessed heritability with structural equation models, using the classical twin design. FA measures from the genu of the corpus callosum were highly heritable, regardless of protocol. Genome-wide analysis of the genu mean FA revealed differences across protocols in the top associations.Entities:
Year: 2012 PMID： 22903274 PMCID： PMC3420973 DOI： 10.1109/ISBI.2012.6235712
Source DB: PubMed Journal: Proc IEEE Int Symp Biomed Imaging ISSN： 1945-7928