Literature DB >> 22903244

Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits.

Kazuya Murata1, Seiya Takano, Megumi Masuda, Munekazu Iinuma, Hideaki Matsuda.   

Abstract

The anti-degranulating activity of flavonoids present in Citrus fruits was comprehensively evaluated. Among these, hesperetin and naringenin, respectively aglycones of hesperidin and narirutin, showed significant activity. The targets of hesperetin and naringenin were found: hesperetin inhibited phosphorylation of Syk and Akt, while naringenin suppressed the expression of Lyn and inhibited the phosphorylation of Akt. These results suggest that hesperetin and naringenin inhibit degranulation by suppression of pathway signals and reduce the symptoms of allergy by inhibiting phosphorylation of Akt, which leads to the suppression of cytokines. In addition, hesperetin showed inhibitory activity against the degranulation induced by calcium ionophores, indicating that hesperetin exerts its inhibitory activity by stabilizing the membrane structure.

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Year:  2012        PMID： 22903244     DOI： 10.1007/s11418-012-0699-y

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  12 in total

1.  [Pharmacological study on citrus fruits. II. Anti-allergic effect of fruit of Citrus unshiu MARKOVICH (2). On flavonoid components].

Authors:  H Matsuda; M Yano; M Kubo; M Iinuma; M Oyama; M Mizuno
Journal:  Yakugaku Zasshi       Date:  1991-03       Impact factor: 0.302

2.  [Pharmacological study on citrus fruits. I. Anti-allergic effect of fruit of Citrus unshiu Markovich (1)].

Authors:  M Kubo; M Yano; H Matsuda
Journal:  Yakugaku Zasshi       Date:  1989-11       Impact factor: 0.302

3.  Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.

Authors:  Kimihisa Itoh; Megumi Masuda; Shunsuke Naruto; Kazuya Murata; Hideaki Matsuda
Journal:  J Nat Med       Date:  2009-07-15       Impact factor: 2.343

4.  Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma.

Authors:  Hikaru Matsumoto; Yoshinori Ikoma; Minoru Sugiura; Masamichi Yano; Yoshinori Hasegawa
Journal:  J Agric Food Chem       Date:  2004-10-20       Impact factor: 5.279

5.  Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice.

Authors:  Tadashi Fujita; Takehumi Shiura; Megumi Masuda; Masashi Tokunaga; Atsushi Kawase; Masahiro Iwaki; Takeshi Gato; Masahiko Fumuro; Katsuaki Sasaki; Naoki Utsunomiya; Hideaki Matsuda
Journal:  J Nat Med       Date:  2007-11-08       Impact factor: 2.343

6.  Flavonoid glycosides and limonoids from Citrus molasses.

Authors:  Masanori Kuroyanagi; Hiromi Ishii; Nobuo Kawahara; Hiroyuki Sugimoto; Hideo Yamada; Kiyoshi Okihara; Osamu Shirota
Journal:  J Nat Med       Date:  2007-09-27       Impact factor: 2.343

7.  Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils.

Authors:  M Tordera; M L Ferrándiz; M J Alcaraz
Journal:  Z Naturforsch C J Biosci       Date:  1994 Mar-Apr

8.  Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.

Authors:  Shoko Kobayashi; Soichi Tanabe
Journal:  Int J Mol Med       Date:  2006-03       Impact factor: 4.101

9.  Inhibitory effects of Citrus hassaku extract and its flavanone glycosides on melanogenesis.

Authors:  Kimihisa Itoh; Noriko Hirata; Megumi Masuda; Shunsuke Naruto; Kazuya Murata; Keitaro Wakabayashi; Hideaki Matsuda
Journal:  Biol Pharm Bull       Date:  2009-03       Impact factor: 2.233

10.  Inhibition of syk activity and degranulation of human mast cells by flavonoids.

Authors:  Michitaka Shichijo; Noriyuki Yamamoto; Hideki Tsujishita; Masahiro Kimata; Hiroichi Nagai; Toshio Kokubo
Journal:  Biol Pharm Bull       Date:  2003-12       Impact factor: 2.233
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  8 in total

1.  Structure-activity relationships of flavanones, flavanone glycosides, and flavones in anti-degranulation activity in rat basophilic leukemia RBL-2H3 cells.

Authors:  Toshiro Noshita; Kaori Miura; Kaoru Ikeda; Hidekazu Ouchi; Takuya Matsumoto; Akihiro Tai
Journal:  J Nat Med       Date:  2018-01-18       Impact factor: 2.343

2.  Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.

Authors:  Yan-Hong Shi; Shu Zhu; Takayuki Tamura; Makoto Kadowaki; Zhengtao Wang; Kayo Yoshimatsu; Katsuko Komatsu
Journal:  J Nat Med       Date:  2016-01-30       Impact factor: 2.343

3.  Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation.

Authors:  Ryota Uchida; Michiko Kato; Yuka Hattori; Hiroko Kikuchi; Emi Watanabe; Katsuumi Kobayashi; Keigo Nishida
Journal:  Int J Mol Sci       Date:  2020-04-02       Impact factor: 5.923

4.  Anti-allergic activity of the Morinda citrifolia extract and its constituents.

Authors:  Kazuya Murata; Yumi Abe; Kaito Shinohara; Megumi Futamura-Masuda; Akemi Uwaya; Fumiyuki Isami; Hideaki Matsuda
Journal:  Pharmacognosy Res       Date:  2014-07

Review 5.  Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health.

Authors:  Xinmiao Lv; Siyu Zhao; Zhangchi Ning; Honglian Zeng; Yisong Shu; Ou Tao; Cheng Xiao; Cheng Lu; Yuanyan Liu
Journal:  Chem Cent J       Date:  2015-12-24       Impact factor: 4.215

6.  Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume).

Authors:  Ryohei Kono; Misa Nakamura; Sachiko Nomura; Naomi Kitano; Tomoko Kagiya; Yoshiharu Okuno; Ken-Ichi Inada; Akihiko Tokuda; Hirotoshi Utsunomiya; Masami Ueno
Journal:  Sci Rep       Date:  2018-08-03       Impact factor: 4.379

Review 7.  Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use.

Authors:  José Antonio Uranga; Vicente Martínez; Raquel Abalo
Journal:  Molecules       Date:  2020-09-20       Impact factor: 4.411

8.  Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-κB.

Authors:  Ji-Ye Lim; Ji-Hyun Lee; Bo-Ri Lee; Mi Ae Kim; Young-Mi Lee; Dae-Ki Kim; Jin Kyeong Choi
Journal:  Molecules       Date:  2020-09-12       Impact factor: 4.411
  8 in total

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