Jennifer A Sumner1, Qixuan Chen2, Andrea L Roberts3, Ashley Winning3, Eric B Rimm4, Paola Gilsanz3, M Maria Glymour5, Shelley S Tworoger6, Karestan C Koenen7, Laura D Kubzansky8. 1. Center for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, New York; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: js4456@cumc.columbia.edu. 2. Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York. 3. Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 4. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 5. Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California. 6. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 7. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Psychiatric and Neurodevelopmental Genetics Unit and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts. 8. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Abstract
BACKGROUND: Posttraumatic stress disorder (PTSD) may contribute to heightened cardiovascular disease risk by promoting a proinflammatory state and impaired endothelial function. Previous research has demonstrated associations of PTSD with inflammatory and endothelial function biomarkers, but most work has been cross-sectional and does not separate the effects of trauma exposure from those of PTSD. METHODS: We investigated associations of trauma exposure and chronic PTSD with biomarkers of inflammation (C-reactive protein and tumor necrosis factor alpha receptor II) and endothelial function (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) in 524 middle-aged women in the Nurses' Health Study II. Using linear mixed models, we examined associations of trauma/PTSD status with biomarkers measured twice, 10 to 16 years apart, in cardiovascular disease-free women, considering either average levels over time (cross-sectional) or change in levels over time (longitudinal). Biomarker levels were log-transformed. Trauma/PTSD status (based on structured diagnostic interviews) was defined as no trauma at either blood draw (n = 175), trauma at blood draw 1 but no PTSD at either draw (n = 175), and PTSD that persisted beyond blood draw 1 (chronic PTSD; n = 174). The reference group was women without trauma. RESULTS: In models adjusted for known potential confounders, women with chronic PTSD had higher average C-reactive protein (B = 0.27, p < .05), tumor necrosis factor alpha receptor II (B = 0.07, p < .01), and intercellular adhesion molecule-1 (B = 0.04, p < .05) levels. Women with trauma but without PTSD had higher average tumor necrosis factor alpha receptor II levels (B = 0.05, p < .05). In addition, women with chronic PTSD had a greater increase in vascular cell adhesion molecule-1 over time (B = 0.003, p < .05). CONCLUSIONS: Increased inflammation and impaired endothelial function may be pathways by which chronic PTSD increases cardiovascular disease risk.
BACKGROUND:Posttraumatic stress disorder (PTSD) may contribute to heightened cardiovascular disease risk by promoting a proinflammatory state and impaired endothelial function. Previous research has demonstrated associations of PTSD with inflammatory and endothelial function biomarkers, but most work has been cross-sectional and does not separate the effects of trauma exposure from those of PTSD. METHODS: We investigated associations of trauma exposure and chronic PTSD with biomarkers of inflammation (C-reactive protein and tumornecrosis factor alpha receptor II) and endothelial function (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) in 524 middle-aged women in the Nurses' Health Study II. Using linear mixed models, we examined associations of trauma/PTSD status with biomarkers measured twice, 10 to 16 years apart, in cardiovascular disease-free women, considering either average levels over time (cross-sectional) or change in levels over time (longitudinal). Biomarker levels were log-transformed. Trauma/PTSD status (based on structured diagnostic interviews) was defined as no trauma at either blood draw (n = 175), trauma at blood draw 1 but no PTSD at either draw (n = 175), and PTSD that persisted beyond blood draw 1 (chronic PTSD; n = 174). The reference group was women without trauma. RESULTS: In models adjusted for known potential confounders, women with chronic PTSD had higher average C-reactive protein (B = 0.27, p < .05), tumornecrosis factor alpha receptor II (B = 0.07, p < .01), and intercellular adhesion molecule-1 (B = 0.04, p < .05) levels. Women with trauma but without PTSD had higher average tumornecrosis factor alpha receptor II levels (B = 0.05, p < .05). In addition, women with chronic PTSD had a greater increase in vascular cell adhesion molecule-1 over time (B = 0.003, p < .05). CONCLUSIONS: Increased inflammation and impaired endothelial function may be pathways by which chronic PTSD increases cardiovascular disease risk.
Authors: Roland von Känel; Chiara C Abbas; Stefan Begré; Hugo Saner; Marie-Louise Gander; Jean-Paul Schmid Journal: Psychiatry Res Date: 2010-05-21 Impact factor: 3.222
Authors: Scott D Nash; Karen J Cruickshanks; Ronald Klein; Barbara E K Klein; F Javier Nieto; Rick Chappell; Carla R Schubert; Michael Y Tsai Journal: J Am Geriatr Soc Date: 2013-07-26 Impact factor: 5.562
Authors: Tianyi Huang; Amy L Shafrir; A Heather Eliassen; Kathryn M Rexrode; Shelley S Tworoger Journal: Am J Epidemiol Date: 2020-07-01 Impact factor: 4.897
Authors: Jennifer A Sumner; Kristen M Nishimi; Karestan C Koenen; Andrea L Roberts; Laura D Kubzansky Journal: Biol Psychiatry Date: 2019-11-14 Impact factor: 13.382
Authors: Vasiliki Michopoulos; Jessica Maples-Keller; Elizabeth I Roger; Francesca L Beaudoin; Jennifer A Sumner; Barbara O Rothbaum; Lauren Hudak; Charles F Gillespie; Ian M Kronish; Samuel A McLean; Kerry J Ressler Journal: Neuropsychopharmacology Date: 2018-11-21 Impact factor: 7.853
Authors: Natalie Hellman; Cassandra A Sturycz; Edward W Lannon; Bethany L Kuhn; Yvette M Güereca; Tyler A Toledo; Michael F Payne; Felicitas A Huber; Mara Demuth; Shreela Palit; Joanna O Shadlow; Jamie L Rhudy Journal: J Pain Date: 2019-02-27 Impact factor: 5.820
Authors: Jeffrey L Kibler; Mindy Ma; Mischa Tursich; Lydia Malcolm; Maria M Llabre; Rachel Greenbarg; Steven N Gold; Jean C Beckham Journal: J Affect Disord Date: 2018-08-07 Impact factor: 4.839
Authors: Bruno B Lima; Muhammad Hammadah; Kobina Wilmot; Brad D Pearce; Amit Shah; Oleksiy Levantsevych; Belal Kaseer; Malik Obideen; Mohamad Mazen Gafeer; Jeong Hwan Kim; Samaah Sullivan; Tené T Lewis; Lei Weng; Lisa Elon; Lian Li; J Douglas Bremner; Paolo Raggi; Arshed Quyyumi; Viola Vaccarino Journal: Brain Behav Immun Date: 2018-08-30 Impact factor: 7.217