PURPOSE: To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss. METHODS: Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourier-domain optical coherence tomography instrument with axial resolution of 4 μm to 4.5 μm and transverse resolution of 10 μm to 15 μm. RESULTS: Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was noted in all eyes by microperimetry or Amsler grid. Fourier-domain optical coherence tomography showed abnormality in the foveal photoreceptor (PR) layer in six eyes from four subjects (67%). These abnormalities include focal loss of the PR layer with microcystoid changes in the macula (n = 2), focal discontinuity of the PR layer (n = 3), and focal elevation and blurring of the PR layer associated with a mild epiretinal membrane (n = 1). Among age-matched control eyes, no foveal PR abnormality was seen. CONCLUSION: Fourier-domain optical coherence tomography detected subtle changes in the foveal PR layer in some eyes with vision loss and central scotoma unexplained with routine clinical diagnostic tests.
PURPOSE: To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss. METHODS: Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourier-domain optical coherence tomography instrument with axial resolution of 4 μm to 4.5 μm and transverse resolution of 10 μm to 15 μm. RESULTS: Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was noted in all eyes by microperimetry or Amsler grid. Fourier-domain optical coherence tomography showed abnormality in the foveal photoreceptor (PR) layer in six eyes from four subjects (67%). These abnormalities include focal loss of the PR layer with microcystoid changes in the macula (n = 2), focal discontinuity of the PR layer (n = 3), and focal elevation and blurring of the PR layer associated with a mild epiretinal membrane (n = 1). Among age-matched control eyes, no foveal PR abnormality was seen. CONCLUSION: Fourier-domain optical coherence tomography detected subtle changes in the foveal PR layer in some eyes with vision loss and central scotoma unexplained with routine clinical diagnostic tests.
Authors: Hideki Koizumi; Richard F Spaide; Yale L Fisher; K Bailey Freund; James M Klancnik; Lawrence A Yannuzzi Journal: Am J Ophthalmol Date: 2008-01-11 Impact factor: 5.258
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Authors: M R Hee; C A Puliafito; C Wong; J S Duker; E Reichel; J S Schuman; E A Swanson; J G Fujimoto Journal: Ophthalmology Date: 1995-05 Impact factor: 12.079
Authors: Suhail Alam; Robert J Zawadzki; Stacey Choi; Christina Gerth; Susanna S Park; Lawrence Morse; John S Werner Journal: Ophthalmology Date: 2006-06-12 Impact factor: 12.079
Authors: Richard F Spaide; Ketan Laud; Howard F Fine; James M Klancnik; Catherine B Meyerle; Lawrence A Yannuzzi; John Sorenson; Jason Slakter; Yale L Fisher; Michael J Cooney Journal: Retina Date: 2006-04 Impact factor: 4.256